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Are There Sex-Specific Differences in Response to Adjunctive Host-Directed Therapies for Tuberculosis?

作者信息

Dutta Noton K, Schneider Bianca E

机构信息

Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Junior Research Group Coinfection, Priority Research Area Infections, Research Center Borstel - Leibniz Lung Center, Borstel, Germany.

出版信息

Front Immunol. 2020 Jul 7;11:1465. doi: 10.3389/fimmu.2020.01465. eCollection 2020.

DOI:10.3389/fimmu.2020.01465
PMID:32733484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7358361/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/7358361/38977701788a/fimmu-11-01465-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/7358361/38977701788a/fimmu-11-01465-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c286/7358361/38977701788a/fimmu-11-01465-g0001.jpg

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Differential effects of sex on tuberculosis location and severity across the lifespan.性别对全生命周期肺结核部位和严重程度的影响差异。

本文引用的文献

1
The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis.辛伐他汀的抗结核活性是通过胆固醇驱动的自噬，经由 AMPK-mTORC1-TFEB 轴来介导的。
J Lipid Res. 2020 Dec;61(12):1617-1628. doi: 10.1194/jlr.RA120000895. Epub 2020 Aug 26.
2
Increased male susceptibility to Mycobacterium tuberculosis infection is associated with smaller B cell follicles in the lungs.男性对结核分枝杆菌感染的易感性增加与肺部的 B 细胞滤泡较小有关。
Sci Rep. 2020 Mar 20;10(1):5142. doi: 10.1038/s41598-020-61503-3.
3
Statin use and risk of tuberculosis: a systemic review of observational studies.
Sci Rep. 2023 Apr 13;13(1):6023. doi: 10.1038/s41598-023-33245-5.
4
Sex-Dependent Differential Expression of Lipidic Mediators Associated with Inflammation Resolution in Patients with Pulmonary Tuberculosis.性别依赖性差异表达的与炎症消退相关的脂质介质与肺结核患者相关。
Biomolecules. 2022 Mar 24;12(4):490. doi: 10.3390/biom12040490.
他汀类药物的使用与结核病风险：观察性研究的系统评价。
Int J Infect Dis. 2020 Apr;93:168-174. doi: 10.1016/j.ijid.2020.01.036. Epub 2020 Jan 23.
4
Reply to Hu et al: Could there be detrimental effects of statin adjunctive TB therapy on immune responses?回复胡等人：他汀类药物辅助结核病治疗会对免疫反应产生有害影响吗？
J Infect Dis. 2020 Jun 29;222(2):336-337. doi: 10.1093/infdis/jiz676.
5
Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice.他汀类药物辅助宿主导向治疗可改善小鼠结核病相关结局。
J Infect Dis. 2020 Mar 16;221(7):1079-1087. doi: 10.1093/infdis/jiz517.
6
Remembering the Host in Tuberculosis Drug Development.结核病药物研发中的宿主记忆。
J Infect Dis. 2019 Apr 19;219(10):1518-1524. doi: 10.1093/infdis/jiy712.
7
Sex differences in tuberculosis.结核病的性别差异。
Semin Immunopathol. 2019 Mar;41(2):225-237. doi: 10.1007/s00281-018-0725-6. Epub 2018 Oct 25.
8
Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype.毒力因子 ESAT-6 驱动巨噬细胞向促炎 M1 表型分化，并随后将其切换为抗炎 M2 表型。
Front Cell Infect Microbiol. 2018 Sep 18;8:327. doi: 10.3389/fcimb.2018.00327. eCollection 2018.
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Interferon-gamma (IFN-γ): Exploring its implications in infectious diseases.干扰素-γ（IFN-γ）：探讨其在传染病中的意义。
Biomol Concepts. 2018 May 30;9(1):64-79. doi: 10.1515/bmc-2018-0007.
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Differential Susceptibility to Infectious Respiratory Diseases between Males and Females Linked to Sex-Specific Innate Immune Inflammatory Response.男性和女性对传染性呼吸道疾病的易感性差异与性别特异性先天免疫炎症反应有关。
Front Immunol. 2017 Dec 13;8:1806. doi: 10.3389/fimmu.2017.01806. eCollection 2017.