哮喘与过敏的共病和多重共病以及对化学品和某些建筑物的不耐受

Comorbidity and Multimorbidity of Asthma and Allergy and Intolerance to Chemicals and Certain Buildings.

作者信息

Lind Nina, Söderholm Anna, Palmquist Eva, Andersson Linus, Millqvist Eva, Nordin Steven

机构信息

Department of Psychology, Umeå University, Umeå (Drs Lind, Söderholm, Palmquist, Andersson, Nordin); Department of Economics, Swedish University of Agricultural Sciences (Dr Lind); Department of Occupational and Public Health Sciences, University of Gävle, Gävle (Dr Andersson); and Asthma and Allergy Research Group, Sahlgrenska University Hospital, Gothenburg, Sweden (Dr Millqvist).

出版信息

J Occup Environ Med. 2017 Jan;59(1):80-84. doi: 10.1097/JOM.0000000000000930.

DOI:10.1097/JOM.0000000000000930

PMID:28045802

Abstract

OBJECTIVES

We tested the hypothesis of high comorbidity between asthma/allergy and chemical intolerance (CI) and between asthma/allergy and building intolerance (BI), and high multimorbidity between asthma/allergy, CI, and BI.

METHODS

Population-based questionnaire data were used from 530 participants with asthma/allergy (allergic asthma, nonallergic asthma, allergic rhinitis, and/or atopic dermatitis), 414 with self-reported and 112 with physician-diagnosed CI, and 165 with self-reported and 47 with physician-diagnosed BI. Separate reference groups were formed for each of the five case groups.

RESULTS

Adjusted odds ratios varied from 4.6 to 13.1 for comorbidity, and from 6.6 to 46.4 for multimorbidity.

CONCLUSION

The large comorbidity and multimorbidity between asthma/allergy, CI, and BI evokes the question as to whether there are similarities in underlying mechanisms between these conditions.

摘要

目的

我们检验了哮喘/过敏与化学不耐受（CI）之间、哮喘/过敏与建筑物不耐受（BI）之间存在高共病率，以及哮喘/过敏、CI和BI之间存在高多重共病率的假设。

方法

使用了基于人群的问卷调查数据，这些数据来自530名患有哮喘/过敏（过敏性哮喘、非过敏性哮喘、过敏性鼻炎和/或特应性皮炎）的参与者、414名自我报告有CI的参与者和112名经医生诊断有CI的参与者，以及165名自我报告有BI的参与者和47名经医生诊断有BI的参与者。为五个病例组中的每一组分别形成了对照人群。