Lind Nina, Söderholm Anna, Palmquist Eva, Andersson Linus, Millqvist Eva, Nordin Steven
Department of Psychology, Umeå University, Umeå (Drs Lind, Söderholm, Palmquist, Andersson, Nordin); Department of Economics, Swedish University of Agricultural Sciences (Dr Lind); Department of Occupational and Public Health Sciences, University of Gävle, Gävle (Dr Andersson); and Asthma and Allergy Research Group, Sahlgrenska University Hospital, Gothenburg, Sweden (Dr Millqvist).
J Occup Environ Med. 2017 Jan;59(1):80-84. doi: 10.1097/JOM.0000000000000930.
We tested the hypothesis of high comorbidity between asthma/allergy and chemical intolerance (CI) and between asthma/allergy and building intolerance (BI), and high multimorbidity between asthma/allergy, CI, and BI.
Population-based questionnaire data were used from 530 participants with asthma/allergy (allergic asthma, nonallergic asthma, allergic rhinitis, and/or atopic dermatitis), 414 with self-reported and 112 with physician-diagnosed CI, and 165 with self-reported and 47 with physician-diagnosed BI. Separate reference groups were formed for each of the five case groups.
Adjusted odds ratios varied from 4.6 to 13.1 for comorbidity, and from 6.6 to 46.4 for multimorbidity.
The large comorbidity and multimorbidity between asthma/allergy, CI, and BI evokes the question as to whether there are similarities in underlying mechanisms between these conditions.
我们检验了哮喘/过敏与化学不耐受（CI）之间、哮喘/过敏与建筑物不耐受（BI）之间存在高共病率，以及哮喘/过敏、CI和BI之间存在高多重共病率的假设。
使用了基于人群的问卷调查数据，这些数据来自530名患有哮喘/过敏（过敏性哮喘、非过敏性哮喘、过敏性鼻炎和/或特应性皮炎）的参与者、414名自我报告有CI的参与者和112名经医生诊断有CI的参与者，以及165名自我报告有BI的参与者和47名经医生诊断有BI的参与者。为五个病例组中的每一组分别形成了对照人群。
共病的调整比值比在4.6至13.1之间，多重共病的调整比值比在6.6至46.4之间。
哮喘/过敏、CI和BI之间存在的高共病率和多重共病率引发了一个问题，即这些病症在潜在机制上是否存在相似之处。
