Sridaran Rita, Nesbit Chadd E
From the *Department of Emergency Medicine, The Western Pennsylvania Hospital; and †Department of Emergency Medicine, Allegheny General Hospital, Pittsburgh, PA.
Pediatr Emerg Care. 2017 Jan;33(1):38-40. doi: 10.1097/PEC.0000000000001000.
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication of the use of certain medications. It is being seen more often in the pediatric population because of the increasing use of both typical and atypical antipsychotics in children. Rapid recognition of NMS is important to emergency physicians because timely treatment can be life saving. Acute dystonia is also a well-known and more common adverse effect of certain types of antipsychotics, more commonly seen with the typical antipsychotics versus the atypical antipsychotics. We describe a case of a pediatric patient who developed an acute dystonic reaction versus NMS soon after starting aripiprazole. We compare this case with the other documented cases of acute dystonia and NMS after initiating aripiprazole in the pediatric population.
抗精神病药恶性综合征（NMS）是使用某些药物时罕见但可能致命的并发症。由于儿童中典型和非典型抗精神病药物的使用增加，在儿科人群中其发病率正越来越高。对于急诊医生来说，快速识别NMS很重要，因为及时治疗可挽救生命。急性肌张力障碍也是某些类型抗精神病药物众所周知且更常见的不良反应，与非典型抗精神病药物相比，在典型抗精神病药物中更常见。我们描述了一名儿科患者在开始使用阿立哌唑后不久出现急性肌张力障碍反应而非NMS的病例。我们将此病例与儿科人群中开始使用阿立哌唑后其他有记录的急性肌张力障碍和NMS病例进行比较。
