Starkstein S E, Preziosi T J, Berthier M L, Bolduc P L, Mayberg H S, Robinson R G
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD.
Brain. 1989 Oct;112 ( Pt 5):1141-53. doi: 10.1093/brain/112.5.1141.
Neuropsychological deficits including cognitive impairment as well as depression are among the most frequent and important mental disorders found in patients with Parkinson's disease (PD). It has never been determined, however, whether there is a specific relationship between cognitive impairment and depression. A consecutive series of patients with PD was therefore examined for the presence of depression and neuropsychological deficits. Severity of depression was found to be the single most important factor associated with the severity of cognitive impairment. When PD patients with major depression were compared with an age and stage-matched group of nondepressed patients with PD using a neuropsychological battery, major depressed patients performed significantly worse than the nondepressed patients on all aspects of neuropsychological function tested. These impairments were most pronounced on frontal lobe tasks.
神经心理学缺陷，包括认知障碍以及抑郁症，是帕金森病（PD）患者中最常见且最重要的精神障碍之一。然而，认知障碍与抑郁症之间是否存在特定关系尚未确定。因此，对一系列连续的PD患者进行了抑郁症和神经心理学缺陷的检查。结果发现，抑郁严重程度是与认知障碍严重程度相关的唯一最重要因素。当使用神经心理测验对患有重度抑郁症的PD患者与年龄和病程匹配的非抑郁PD患者组进行比较时，重度抑郁患者在所有测试的神经心理功能方面的表现均明显差于非抑郁患者。这些损害在额叶任务上最为明显。
