Condés-Lara M, Omaña Zapata I, León-Olea M, Sánchez-Alvarez M
Departamento de Neurofisiología, Instituto Mexicano de Psiquiatria, Mexico.
Brain Res. 1989 Oct 9;499(1):145-52. doi: 10.1016/0006-8993(89)91144-x.
There is evidence for the existence of a descending pain suppression system, but also there are data supporting the hypothesis for the modulation of pain at higher central nervous system levels. In the present study we give evidence for a possible ascending pain modulation pathway which involves the dorsal raphe (DR), the centralis lateralis nucleus (CL) of the thalamus and the medial prefrontal cortex (PFCx). Urethane-anesthetized rats were used. Simultaneous single unit recordings were done in the CL and PFCx regions under noxious and DR stimulations. Cells responding to both types of stimuli exhibit duration responses directly related to the duration of the stimuli. Thus, from our results we conclude a DR influence upon CL and PFCx structures that are involved in the coding of nociceptive information. A possible route for an ascending pain modulation path is proposed.
有证据表明存在下行性疼痛抑制系统，但也有数据支持在中枢神经系统较高水平对疼痛进行调制的假说。在本研究中，我们提供了一条可能的上行性疼痛调制通路的证据，该通路涉及中缝背核（DR）、丘脑外侧中央核（CL）和内侧前额叶皮质（PFCx）。使用了乌拉坦麻醉的大鼠。在有害刺激和DR刺激下，同时在CL和PFCx区域进行单神经元记录。对两种刺激都有反应的细胞表现出与刺激持续时间直接相关的持续时间反应。因此，从我们的结果中我们得出结论，DR对参与伤害性信息编码的CL和PFCx结构有影响。提出了一条上行性疼痛调制通路的可能途径。
