Balducci L, Chapman S W, Little D D, Hardy C L
Veterans Administration Medical Center, Bay Pines, Florida.
Cancer. 1989 Dec 1;64(11):2250-3. doi: 10.1002/1097-0142(19891201)64:11<2250::aid-cncr2820641111>3.0.co;2-x.
Eosinophilia is an unusual paraneoplastic manifestation. The authors describe for the first time the association of eosinophilia and metastatic medullary carcinoma of the thyroid. The eosinophil count normalized during remission after chemotherapy but increased at time of relapse. The patient's serum enhanced eosinophilic differentiation of human multipotential hemopoietic precursors but was inhibitory to in vitro growth of murine myelopoietic precursors. The number of multipotential colonies which could be cultured in vitro was lower in the patient's peripheral blood than in normal controls. The authors conclude that a tumor-related circulating factor caused eosinophilia by inducing eosinophilic differentiation and inhibiting myeloid differentiation. Such a mechanism of paraneoplastic eosinophilia has not been previously described.
嗜酸性粒细胞增多是一种不寻常的副肿瘤表现。作者首次描述了嗜酸性粒细胞增多与甲状腺转移性髓样癌的关联。化疗缓解期嗜酸性粒细胞计数恢复正常，但复发时又升高。患者血清增强了人类多能造血前体的嗜酸性分化，但对小鼠骨髓造血前体的体外生长有抑制作用。患者外周血中可体外培养的多能集落数量低于正常对照组。作者得出结论，一种肿瘤相关的循环因子通过诱导嗜酸性分化和抑制髓系分化导致嗜酸性粒细胞增多。这种副肿瘤性嗜酸性粒细胞增多的机制此前尚未有过描述。
