Teoh S C, Siow W Y, Tan H T
Department of General Surgery, National University of Singapore, Singapore.
Singapore Med J. 2000 May;41(5):232-4.
Peripheral blood eosinophilia is a well-recognised but unusual manifestation of malignancy, and may represent a paraneoplastic phenomenon. We present a case of poorly differentiated adenocarcinoma of the stomach associated with severe peripheral blood eosinophilia A 55-year old man was admitted for abdominal pain of one week duration. An incidental finding of leucocytosis with eosinophilia was noted. After excluding haematological and infectious causes, an oesophagogastroduodenoscopy (OGD) followed by biopsy confirmed the diagnosis. Eosinophilia appears to be a response to cytokine production,and treatment is aimed at the underlying malignancy, and reducing the eosinophil count when necessary, to prevent end-organ damage. Studies have shown that peripheral eosinophilia is associated with disseminated, metastatic disease and hence signifies a poor prognosis,whereas tissue eosinophilia in advanced cancer has a better survival rate.
外周血嗜酸性粒细胞增多是一种公认但不常见的恶性肿瘤表现，可能代表一种副肿瘤现象。我们报告一例胃低分化腺癌伴严重外周血嗜酸性粒细胞增多的病例。一名55岁男性因持续一周的腹痛入院。偶然发现白细胞增多伴嗜酸性粒细胞增多。排除血液学和感染性病因后，进行了食管胃十二指肠镜检查（OGD），随后活检确诊。嗜酸性粒细胞增多似乎是对细胞因子产生的一种反应，治疗旨在针对潜在的恶性肿瘤，并在必要时降低嗜酸性粒细胞计数，以防止终末器官损伤。研究表明，外周血嗜酸性粒细胞增多与播散性转移性疾病相关，因此预示预后不良，而晚期癌症中的组织嗜酸性粒细胞增多则有较好的生存率。
