Choi Ji Hyun, Lee Seung Keun, Gil Young Eun, Ryu Jia, Jung-Choi Kyunghee, Kim Hyunjoo, Choi Jun Young, Park Sun Ah, Lee Hyang Woon, Yun Ji Young
Department of Neurology, Ewha Womans University School of Medicine, Ewha Womans University Mokdong Hospital, Seoul, Korea.
Department of Neurology, Soonchunhyang University School of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
J Korean Med Sci. 2017 Feb;32(2):371-376. doi: 10.3346/jkms.2017.32.2.371.
Methanol poisoning results in neurological complications including visual disturbances, bilateral putaminal hemorrhagic necrosis, parkinsonism, cerebral edema, coma, or seizures. Almost all reported cases of methanol poisoning are caused by oral ingestion of methanol. However, recently there was an outbreak of methanol poisoning via non-oral exposure that resulted in severe neurological complications to a few workers at industrial sites in Korea. We present 3 patients who had severe neurological complications resulting from non-oral occupational methanol poisoning. Even though initial metabolic acidosis and mental changes were improved with hemodialysis, all of the 3 patients presented optic atrophy and ataxia or parkinsonism as neurological complications resulting from methanol poisoning. In order to manage it adequately, as well as to prevent it, physicians should recognize that methanol poisoning by non-oral exposure can cause neurologic complications.
甲醇中毒会导致神经系统并发症，包括视觉障碍、双侧壳核出血性坏死、帕金森综合征、脑水肿、昏迷或癫痫发作。几乎所有报告的甲醇中毒病例都是由口服甲醇引起的。然而，最近韩国一些工业场所发生了因非口服接触导致的甲醇中毒事件，致使数名工人出现严重的神经系统并发症。我们报告了3例因非口服职业性甲醇中毒导致严重神经系统并发症的患者。尽管通过血液透析初始代谢性酸中毒和精神状态改变有所改善，但这3例患者均出现了视神经萎缩以及共济失调或帕金森综合征等甲醇中毒所致的神经系统并发症。为了妥善处理并预防此类情况，医生应认识到非口服接触甲醇中毒可引发神经系统并发症。
