Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH, USA; The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Kenyon College, Gambier, OH, USA.
Pancreatology. 2019 Oct;19(7):951-956. doi: 10.1016/j.pan.2019.09.009. Epub 2019 Sep 20.
Cathepsin E (CTSE) is an intracellular, hydrolytic aspartic protease found to be expressed in cells of the immune and gastrointestinal systems, lymphoid tissues, erythrocytes, and cancer cells. The precise functions are not fully understood; however, various studies have investigated its numerous cell-type specific roles. CTSE expression has been shown to be a potential early biomarker for pancreatic ductal adenocarcinoma (PDAC). PDAC patients have low survival rates mostly due to the lack of early detection methods. CTSE-specific activity probes have been developed and tested to assist in tumor imaging and functional studies investigating the role of CTSE expression in PDAC tumors. Furthermore, a CTSE protease-specific, photodynamic therapy pro-drug was developed to explore its potential use to treat tumors that express CTSE. Since CTSE is expressed in pancreatic diseases that are risk factors for PDAC, such as pancreatic cysts and chronic pancreatitis, learning about its function in these disease types could assist in early PDAC detection and in understanding the biology of PDAC progression. Overall, CTSE expression and activity shows potential to detect PDAC and other pancreatic diseases. Further research is needed to fully understand its functions and potential translational applicability.
组织蛋白酶 E (CTSE) 是一种细胞内的、水解天冬氨酸的蛋白酶，存在于免疫系统和胃肠道系统、淋巴组织、红细胞和癌细胞的细胞中。其确切功能尚未完全了解；然而，各种研究已经调查了其众多细胞类型特异性的作用。CTSE 的表达已被证明是胰腺导管腺癌 (PDAC) 的潜在早期生物标志物。PDAC 患者的生存率很低，主要是因为缺乏早期检测方法。已经开发并测试了 CTSE 特异性活性探针，以协助肿瘤成像和功能研究，调查 CTSE 表达在 PDAC 肿瘤中的作用。此外，还开发了一种针对 CTSE 蛋白酶的光动力治疗前药，以探索其在表达 CTSE 的肿瘤治疗中的潜在用途。由于 CTSE 在 PDAC 的风险因素，如胰腺囊肿和慢性胰腺炎等胰腺疾病中表达，了解其在这些疾病类型中的功能可能有助于早期检测 PDAC 并了解 PDAC 进展的生物学。总的来说，CTSE 的表达和活性显示出检测 PDAC 和其他胰腺疾病的潜力。需要进一步的研究来充分了解其功能和潜在的转化适用性。
