Alam Mohammad Zubair, Alam Qamre, Kamal Mohammad Amjad, Jiman-Fatani Asif Ahmad, Azhar Esam I, Khan Mohammad Azhar, Haque Absarul
King Fahd Medical Research Center, King Abdulaziz University, P. O. Box 80216, Jeddah 21589, Saudi Arabia.
King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Curr Top Med Chem. 2017;17(12):1390-1399. doi: 10.2174/1568026617666170103164040.
Recent studies have shown that bacterial and viral infections are risk factors for various neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Multiple Sclerosis (MS), Alzheimer's disease (AD), and Lyme disease (LD). However, it is still controversial how the infections play a role in neurological diseases progression. Infections in central nervous system may lead multiple damages in infected and neighboring cells. The infection leads to the activation of inflammatory processes and host immune responses, which acts as defense mechanism and also causes damage to the host neuronal functions and viability. Several bacterial and viral pathogens have been reported for neurodegeneration, such as the production and deposit of misfolded protein aggregates, oxidative stress, deficient autophagic processes, synaptopathies and neuronal death. These effects may act in combination with other factors, like aging, metabolic diseases and the genetic makeup of the host. We will focus in this review on the possible link between neurodegeneration and infections particularly Chlamydophila pneumoniae, Borrelia burgdorferi, Mycoplasma etc.
最近的研究表明，细菌和病毒感染是多种神经退行性疾病的危险因素，如肌萎缩侧索硬化症（ALS）、多发性硬化症（MS）、阿尔茨海默病（AD）和莱姆病（LD）。然而，感染如何在神经疾病进展中发挥作用仍存在争议。中枢神经系统感染可能导致受感染细胞和邻近细胞的多种损伤。感染会导致炎症过程和宿主免疫反应的激活，这既是一种防御机制，也会对宿主神经元功能和活力造成损害。几种细菌和病毒病原体已被报道与神经退行性变有关，如错误折叠蛋白聚集体的产生和沉积、氧化应激、自噬过程缺陷、突触病变和神经元死亡。这些影响可能与其他因素共同作用，如衰老、代谢疾病和宿主的基因构成。在本综述中，我们将重点关注神经退行性变与感染之间的可能联系，特别是肺炎衣原体、伯氏疏螺旋体、支原体等。
