Frydrychowicz Clara, Pasieka Bastian, Pierer Matthias, Mueller Wolf, Petros Sirak, Weidhase Lorenz
Department of Neuropathology, University Hospital Leipzig, Liebigstrasse 26, House G, 04103, Leipzig, Germany.
Medical Intensive Care Unit, University Hospital Leipzig, Leipzig, Germany.
J Med Case Rep. 2017 Jan 4;11(1):8. doi: 10.1186/s13256-016-1169-z.
Rhabdomyolysis is a widely recognized yet rare complication in statin use. Rhabdomyolysis might be triggered by the prescription of high doses of statins or by statin accumulation due to interactions with concomitant medication. Muscle cell destruction as evidenced by myoglobin elevation can induce potentially life-threatening acute renal failure.
We report a case of a 70-year-old obese white man with sudden onset of severe rhabdomyolysis with consecutive renal failure. His medication included low-dose simvastatin, which he had taken for 6 years up until the event. The statin was withdrawn immediately. After 3 days of veno-venous hemofiltration his renal function was completely restored.
Clinicians in both primary and special care might be unaware that side effects of statins do occur even after a long uneventful statin medication; they should be advised not to exclude that possibility upfront, even if a patient has tolerated the medication for years.
横纹肌溶解是他汀类药物使用中一种广为人知但罕见的并发症。横纹肌溶解可能由高剂量他汀类药物的处方引发，或因与同时服用的药物相互作用导致他汀类药物蓄积而引发。肌红蛋白升高所证实的肌肉细胞破坏可诱发潜在危及生命的急性肾衰竭。
我们报告一例70岁肥胖白人男性，突然发生严重横纹肌溶解并伴有连续性肾衰竭。他的用药包括低剂量辛伐他汀，在此次事件发生前他已服用6年。他汀类药物立即停用。经过3天的静脉-静脉血液滤过，他的肾功能完全恢复。
基层医疗和专科护理的临床医生可能未意识到，即使在长期无不良事件的他汀类药物治疗后，他汀类药物的副作用仍会发生；应建议他们即使患者多年来耐受该药物，也不应预先排除这种可能性。
