Valenzise Mariella, Aversa Tommaso, Zirilli Giuseppina, Salzano Giuseppina, Corica Domenico, Santucci Simona, De Luca Filippo
Department of Human Pathology of Adulthood and Childhood, University of Messina, via Consolare Valeria, 98125, Messina, Italy.
Ital J Pediatr. 2017 Jan 3;43(1):2. doi: 10.1186/s13052-016-0322-z.
Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyroid status is distinctly higher in the SH children with Hashimoto's thyroiditis (HT). This risk is even higher in the cases with both HT-related SH and chromosomal abnormalities, such as Turner or Down's syndrome.
本评论的目的是根据不同病因报告关于亚临床甲状腺功能减退症（SH）自然史的最新观点。在特发性SH儿童中，自然转归通常较好，即使经过长期随访，仍有很大比例的病例恢复为甲状腺功能正常或仍为亚临床甲状腺功能减退。相比之下，患有桥本甲状腺炎（HT）的SH儿童甲状腺状态显著恶化的风险明显更高。在患有与HT相关的SH且伴有染色体异常（如特纳综合征或唐氏综合征）的病例中，这种风险甚至更高。
