Vejvodova Sarka, Spidlen Vladimir, Mukensnabl Petr, Krakorova Gabriela, Molacek Jiri, Vodicka Josef
Clinic of Surgery, Faculty of Medicine in Pilsen, Charles University in Prague, University Hospital Pilsen, Pilsen, Czech Republic.
Ann Thorac Cardiovasc Surg. 2017 Feb 20;23(1):12-18. doi: 10.5761/atcs.oa.16-00108. Epub 2016 Dec 28.
solitary fibrous tumors (SFT) represent a heterogeneous group of primary pleural neoplasms with a low incidence rate and of which the biological origin, which consists of mesenchymal cells, is uncertain.
The authors present herewith a retrospective analysis of 22 patients with SFTs who were diagnosed and surgically treated between the years 2000-2015. The preoperative tumors were successfully verified morphologically by transthoracic core needle biopsy under CT control in 27.3% of patients. Surgical approaches were either posterolateral thoracotomy or videothoracoscopy. The follow-up median was 45 months (range 1-188 months).
Twenty tumors were surgically removed radically, two tumors were found to be unresectable due to the considerable tumor size. From histological point of view 81.8% of tumors were SFT with low malignant potential, 18.2% of tumors with high malignant potential. Despite the radical extirpation of the SFT, it relapsed in two patients.
The gold standard of SFT treatment is radical surgical removal; however, patients at risk of recurrence require additional follow-ups. The results of adjuvant therapy in recurrent and malignant forms of SFTs are the subject of discussion and further study.
孤立性纤维瘤（SFT）是一组异质性的原发性胸膜肿瘤，发病率较低，其由间充质细胞组成的生物学起源尚不确定。
作者在此对2000年至2015年间诊断并接受手术治疗的22例SFT患者进行回顾性分析。27.3%的患者术前肿瘤在CT引导下经胸芯针穿刺活检成功进行了形态学验证。手术方式为后外侧开胸或电视胸腔镜手术。中位随访时间为45个月（范围1 - 188个月）。
20例肿瘤被根治性切除，2例因肿瘤体积过大而无法切除。从组织学角度看，81.8%的肿瘤为低恶性潜能的SFT，18.2%为高恶性潜能的肿瘤。尽管SFT被根治性切除，但仍有2例患者复发。
SFT治疗的金标准是根治性手术切除；然而，有复发风险的患者需要额外的随访。SFT复发和恶性形式的辅助治疗结果是讨论和进一步研究的主题。
