血液系统恶性肿瘤化疗后乙肝病毒的迟发性再激活：一例病例报告及文献综述
Late Reactivation of Hepatitis B Virus after Chemotherapies for Hematological Malignancies: A Case Report and Review of the Literature.
作者信息
Yamada Toshiki, Nannya Yasuhito, Suetsugu Atsushi, Shimizu Shogo, Sugihara Junichi, Shimizu Masahito, Seishima Mitsuru, Tsurumi Hisashi
机构信息
Department of Hematology, Gifu Prefectural Medical Center, Japan.
出版信息
Intern Med. 2017;56(1):115-118. doi: 10.2169/internalmedicine.56.7468. Epub 2017 Jan 1.
Abstract
Reactivation of hepatitis B virus (HBV) is a serious complication of immunosuppressive therapy and cytotoxic chemotherapy. The optimal duration of HBV-DNA monitoring for at-risk patients depends on the clinical features of reactivation, especially the range of potency from therapies to reactivation. We present a case of very late reactivation after chemotherapy for lymphoma and review previous reports of late reactivation cases. We also underscore the significance of developing an indicator for anti-HBV immunity which can be used to determine the optimal monitoring period.
摘要
乙型肝炎病毒（HBV）再激活是免疫抑制治疗和细胞毒性化疗的严重并发症。对有风险患者进行HBV-DNA监测的最佳持续时间取决于再激活的临床特征，尤其是从治疗到再激活的效力范围。我们报告一例淋巴瘤化疗后非常晚发生的再激活病例，并回顾既往关于晚发性再激活病例的报告。我们还强调开发一种抗HBV免疫指标的重要性，该指标可用于确定最佳监测期。
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Hepatitis B virus reactivation following allogeneic hematopoietic stem cell transplantation.异基因造血干细胞移植后乙肝病毒再激活
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Reactivation of hepatitis B virus following systemic chemotherapy for malignant lymphoma.恶性淋巴瘤全身化疗后乙型肝炎病毒再激活
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