Fu Juanjuan, Wang Hongxing, Deng Lingxiao, Li Jianan
Department of Rehabilitation Medicine of 1st Affiliated Hospital of Nanjing Medical University, School of Rehabilitation Medicine of Nanjing Medical University, Nanjing, China; Binzhou Medical University, Yantai, China.
Department of Rehabilitation Medicine of 1st Affiliated Hospital of Nanjing Medical University, School of Rehabilitation Medicine of Nanjing Medical University, Nanjing, China.
Neural Plast. 2016;2016:4039580. doi: 10.1155/2016/4039580. Epub 2016 Dec 6.
The exercise training is an effective therapy for spinal cord injury which has been applied to clinic. Traditionally, the exercise training has been considered to improve spinal cord function only through enhancement, compensation, and replacement of the remaining function of nerve and muscle. Recently, accumulating evidences indicated that exercise training can improve the function in different levels from end-effector organ such as skeletal muscle to cerebral cortex through reshaping skeletal muscle structure and muscle fiber type, regulating physiological and metabolic function of motor neurons in the spinal cord and remodeling function of the cerebral cortex. We compiled published data collected in different animal models and clinical studies into a succinct review of the current state of knowledge.
运动训练是一种已应用于临床的脊髓损伤有效治疗方法。传统上，运动训练仅被认为是通过增强、补偿和替代神经与肌肉的剩余功能来改善脊髓功能。最近，越来越多的证据表明，运动训练可通过重塑骨骼肌结构和肌纤维类型、调节脊髓运动神经元的生理和代谢功能以及重塑大脑皮层功能，从骨骼肌等终末效应器器官到大脑皮层的不同水平改善功能。我们将在不同动物模型和临床研究中收集的已发表数据整理成一篇关于当前知识状态的简要综述。
