Yuan C D
Zhonghua Liu Xing Bing Xue Za Zhi. 1989 Aug;10(4):210-4.
This paper reports the result of the immune response and reactions to simultaneous administration of Japanese B encephalitis vaccine, measles and hepatitis B vaccine. 215 children (0-9 months of age) were divided into three groups. Group one was vaccinated with hepatitis B vaccine alone, group two was vaccinated with Japanese B encephalitis vaccine, measles vaccine, and group three was Vaccinated with hepatitis B vaccine, Japanese B encephalitis vaccine and measles vaccine simultaneously. The result of the immune response to the combination of hepatitis B vaccine with Japanese B encephalitis vaccine were similar to that observed after immunization with each vaccine alone. But the result of the immune response to the combination of hepatitis B vaccine with measles vaccine were lower than to that observed after immunization with measles vaccine alone. The general reaction of all vaccine were mild, no significant difference between each group was noted. The study demonstrated that children can not be immunized with hepatitis B vaccine and measles vaccine simultaneously but can be immunized with hepatitis B Vaccine and Japanese B encephalitis vaccine.
本文报告了同时接种乙型脑炎疫苗、麻疹疫苗和乙型肝炎疫苗的免疫反应及反应结果。215名儿童（0至9个月大）被分为三组。第一组仅接种乙型肝炎疫苗，第二组接种乙型脑炎疫苗、麻疹疫苗，第三组同时接种乙型肝炎疫苗、乙型脑炎疫苗和麻疹疫苗。乙型肝炎疫苗与乙型脑炎疫苗联合接种的免疫反应结果与单独接种每种疫苗后观察到的结果相似。但乙型肝炎疫苗与麻疹疫苗联合接种的免疫反应结果低于单独接种麻疹疫苗后观察到的结果。所有疫苗的一般反应均较轻，各组之间未发现显著差异。该研究表明，儿童不能同时接种乙型肝炎疫苗和麻疹疫苗，但可以同时接种乙型肝炎疫苗和乙型脑炎疫苗。
