Miller William B, Torday John S
Independent Researcher, Paradise Valley, AZ, 85253, USA.
Harbor-UCLA Medical Center, Torrance, CA, 90502, USA.
Clin Transl Med. 2017 Dec;6(1):2. doi: 10.1186/s40169-016-0131-4. Epub 2017 Jan 3.
Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition based evolution is suggested as an alternative approach to cancer development and progression in which neoplastic cells of differing karyotypes and cellular lineages are assessed as self-referential agencies with purposive participation within tissue microenvironments. As distinct self-aware entities, neoplastic cells occupy unique participant/observer status within tissue ecologies. In consequence, neoplastic proliferation by clonal lineages is enhanced by the advantaged utilization of ecological resources through flexible re-connection with progenitor evolutionary stages.
癌症通常被视为一种病理过程，其特征是染色体畸变和克隆性扩增，在适应性细胞生态系统中受到随机达尔文选择的影响。基于认知的进化被认为是癌症发生和发展的另一种途径，在这种途径中，不同核型和细胞谱系的肿瘤细胞被视为具有自我参照能力的主体，在组织微环境中有目的地参与其中。作为独特的自我意识实体，肿瘤细胞在组织生态中占据着独特的参与者/观察者地位。因此，通过与祖先进化阶段的灵活重新连接，肿瘤细胞系通过对生态资源的优势利用来增强克隆谱系的增殖。
