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Genetics of T2DM in 2016: Biological and translational insights from T2DM genetics.

作者信息

McCarthy Mark I

机构信息

Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Old Road, Headington, Oxford OX3 7LJ, UK; and at the Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford OX3 7BN, UK.

出版信息

Nat Rev Endocrinol. 2017 Feb;13(2):71-72. doi: 10.1038/nrendo.2016.212. Epub 2017 Jan 4.

DOI:10.1038/nrendo.2016.212
PMID:28051116
Abstract
摘要

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The effect of host genetics on the gut microbiome.宿主遗传学对肠道微生物组的影响。
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The Difficult Journey from Genome-wide Association Studies to Pathophysiology: The Melatonin Receptor 1B (MT2) Paradigm.
营养摄入依赖性胰高血糖素样肽-1 受体基因多态性与胰岛素分泌的关联。
Sci Rep. 2020 Oct 2;10(1):16382. doi: 10.1038/s41598-020-71853-7.
4
Different prevalence of T2DM risk alleles in Roma population in comparison with the majority Czech population.与捷克多数族裔相比,罗姆人群体中 T2DM 风险等位基因的患病率不同。
Mol Genet Genomic Med. 2020 Sep;8(9):e1361. doi: 10.1002/mgg3.1361. Epub 2020 Jun 24.
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Precision Medicine in Non Communicable Diseases.非传染性疾病中的精准医学。
Int J Mol Cell Med. 2019 Winter;8(Suppl1):1-18. doi: 10.22088/IJMCM.BUMS.8.2.1. Epub 2019 Jul 25.
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High-Throughput Approaches onto Uncover (Epi)Genomic Architecture of Type 2 Diabetes.用于揭示2型糖尿病(表观)基因组结构的高通量方法。
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Spectrum of mutations in monogenic diabetes genes identified from high-throughput DNA sequencing of 6888 individuals.从6888名个体的高通量DNA测序中鉴定出的单基因糖尿病基因突变谱。
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从全基因组关联研究到病理生理学的艰难历程:褪黑素受体1B(MT2)范例
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