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人卵巢癌中S100的表达及预后综合分析：一项加强观察性研究报告规范（STROBE）研究

Comprehensive analysis of the expression and prognosis for S100 in human ovarian cancer: A STROBE study.

作者信息

Xu Hong-Yu, Song Hua-Mei, Zhou Quan

机构信息

Department of Gynecology and Obstetrics, the Second People's Hospital of Yichang, China Three Gorges University.

Department of Gynecology and Obstetrics, the People's Hospital of China Three Gorges University/the First People's Hospital of Yichang, Yichang, Hubei, China.

出版信息

Medicine (Baltimore). 2020 Nov 20;99(47):e22777. doi: 10.1097/MD.0000000000022777.

DOI:10.1097/MD.0000000000022777
PMID:33217795
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7676574/
Abstract

S100 family members are frequently deregulated in human malignancies, including ovarian cancer. However, the prognostic roles of each individual S100 family member in ovarian cancer (OC) patients remain elusive. In the present study, we assessed the prognostic roles and molecular function of 20 individual members of the S100 family in OC patients using GEPIA, Kaplan-Meier plotter, SurvExpress, GeneMANIA and Funrich database. Our results indicated that the mRNA expression levels of S100A1, S100A2, S100A4, S100A5, S100A11, S100A14, and S100A16 were significantly upregulated in patients with OC, and high mRNA expression of S100A1, S100A3, S100A5, S100A6, and S100A13 were significantly correlated with better overall survival, while increased S100A2, S100A7A, S100A10, and S100A11 mRNA expressions were associated with worse prognosis in OC patients. In stratified analysis, the trends of high expression of individual S100 members were nearly the same in different pathological grade, clinical stage, TP53 mutation status, and treatment. More importantly, S100 family signatures may be useful potential prognostic markers for OC. These findings suggest that S100 family plays a vital role in prognostic value and could potentially be an S100-targeted inhibitors for OC patients.

摘要

S100家族成员在包括卵巢癌在内的人类恶性肿瘤中经常发生失调。然而，每个S100家族成员在卵巢癌（OC）患者中的预后作用仍然难以捉摸。在本研究中，我们使用GEPIA、Kaplan-Meier绘图仪、SurvExpress、GeneMANIA和Funrich数据库评估了S100家族20个成员在OC患者中的预后作用和分子功能。我们的结果表明，S100A1、S100A2、S100A4、S100A5、S100A11、S100A14和S100A16的mRNA表达水平在OC患者中显著上调，S100A1、S100A3、S100A5、S100A6和S100A13的高mRNA表达与更好的总生存期显著相关，而S100A2、S100A7A、S100A10和S100A11的mRNA表达增加与OC患者的预后较差相关。在分层分析中，不同病理分级、临床分期、TP53突变状态和治疗中，单个S100成员高表达的趋势几乎相同。更重要的是，S100家族特征可能是OC有用的潜在预后标志物。这些发现表明，S100家族在预后价值中起着至关重要的作用，并且可能成为OC患者的S100靶向抑制剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/3357281d58bf/medi-99-e22777-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/7c8ee7b86ea3/medi-99-e22777-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/977436823528/medi-99-e22777-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/41cac7b0e2cb/medi-99-e22777-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/1f505b1f6ad1/medi-99-e22777-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/7791ec251e59/medi-99-e22777-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/3357281d58bf/medi-99-e22777-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/7c8ee7b86ea3/medi-99-e22777-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/977436823528/medi-99-e22777-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/41cac7b0e2cb/medi-99-e22777-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/1f505b1f6ad1/medi-99-e22777-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/7791ec251e59/medi-99-e22777-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f25/7676574/3357281d58bf/medi-99-e22777-g006.jpg

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