Department of Urology, Chung Shan Medical University Hospital, Taichung, Taiwan.
School of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Sci Rep. 2017 Jan 4;7:40003. doi: 10.1038/srep40003.
The variation in mortality-to-incidence ratios (MIRs) among countries reflects the clinical outcomes and the available interventions for colorectal cancer treatments. The association between MIR of prostate cancer and cancer care disparities among countries is an interesting issue that is rarely investigated. For the present study, cancer incidence and mortality rates were obtained from the GLOBOCAN 2012 database. The rankings and total expenditures on health of various countries were obtained from the World Health Organization (WHO). The association between variables was analyzed by linear regression analyses. In this study, we estimated the role of MIRs from 35 countries that had a prostate cancer incidence greater than 5,000 cases per year. As expected, high prostate cancer incidence and mortality rates were observed in more developed regions, such as Europe and the Americas. However, the MIRs were 2.5 times higher in the less developed regions. Regarding the association between MIR and cancer care disparities, countries with good WHO ranking and high total expenditures on health/gross domestic product (GDP) were significant correlated with low MIR. The MIR variation for prostate cancer correlates with cancer care disparities among countries further support the role of cancer care disparities in clinical outcome.
各国之间死亡率与发病率比（MIR）的差异反映了结直肠癌治疗的临床结果和可获得的干预措施。前列腺癌的 MIR 与各国之间癌症护理差异之间的关联是一个很少被研究的有趣问题。在本研究中，癌症发病率和死亡率数据来自 GLOBOCAN 2012 数据库。各国的排名和卫生总支出数据来自世界卫生组织（WHO）。通过线性回归分析研究变量之间的关联。在这项研究中，我们估计了来自 35 个每年前列腺癌发病率超过 5000 例的国家的 MIR 作用。正如预期的那样，在欧洲和美洲等较发达地区，观察到较高的前列腺癌发病率和死亡率。然而，在欠发达地区，MIR 要高出 2.5 倍。关于 MIR 与癌症护理差异之间的关联，在 WHO 排名较好和卫生总支出/国内生产总值（GDP）较高的国家，与低 MIR 显著相关。前列腺癌的 MIR 变化与各国之间的癌症护理差异进一步支持了癌症护理差异在临床结果中的作用。
