辣木改善人干细胞脂肪生成分化过程中的脂质代谢。

Moringa oleifera Lam. improves lipid metabolism during adipogenic differentiation of human stem cells.

作者信息

Barbagallo I, Vanella L, Distefano A, Nicolosi D, Maravigna A, Lazzarino G, Di Rosa M, Tibullo D, Acquaviva R, Li Volti G

机构信息

Department of Drug Sciences, University of Catania, Catania, Italy.

出版信息

Eur Rev Med Pharmacol Sci. 2016 Dec;20(24):5223-5232.

PMID:28051244

Abstract

OBJECTIVE

Moringa oleifera Lam., a multipurpose tree, is used traditionally for its nutritional and medicinal properties. It has been used for the treatment of a variety of conditions, including inflammation, cancer and metabolic disorders.

MATERIALS AND METHODS

We investigated the effect of Moringa oleifera Lam. on adipogenic differentiation of human adipose-derived mesenchymal stem cells and its impact on lipid metabolism and cellular antioxidant systems.

RESULTS

We showed that Moringa oleifera Lam. treatment during adipogenic differentiation reduces inflammation, lipid accumulation and induces thermogenesis by activation of uncoupling protein 1 (UCP1), sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor alpha (PPARα), and coactivator 1 alpha (PGC1α). In addition, Moringa oleifera Lam. induces heme oxygenase-1 (HO-1), a well established protective and antioxidant enzyme. Finally Moringa oleifera Lam. significantly decreases the expression of molecules involved in adipogenesis and upregulates the expression of mediators involved in thermogenesis and lipid metabolism.

CONCLUSIONS

Our results suggest that Moringa oleifera Lam. may promote the brown remodeling of white adipose tissue inducing thermogenesis and improving metabolic homeostasis.

摘要

目的

辣木是一种多用途树木，传统上因其营养和药用特性而被使用。它已被用于治疗多种病症，包括炎症、癌症和代谢紊乱。

材料与方法

我们研究了辣木对人脂肪来源间充质干细胞成脂分化的影响及其对脂质代谢和细胞抗氧化系统的作用。

结果

我们发现，在成脂分化过程中用辣木处理可减轻炎症、减少脂质积累，并通过激活解偶联蛋白1（UCP1）、沉默调节蛋白1（SIRT1）、过氧化物酶体增殖物激活受体α（PPARα）和辅激活因子1α（PGC1α）诱导产热。此外，辣木可诱导血红素加氧酶-1（HO-1），这是一种公认的具有保护作用的抗氧化酶。最后，辣木显著降低参与脂肪生成的分子的表达，并上调参与产热和脂质代谢的介质的表达。