三种紫堇科（APG II系统下的风信子科）植物的植物化学研究
Phytochemical Investigations of Three Rhodocodon (Hyacinthaceae Sensu APG II) Species.
作者信息
Schwikkard Sianne, Alqahtani Alaa, Knirsch Walter, Wetschnig Wolfgang, Jaksevicius Andrius, Opara Elizabeth I, Langat Moses K, Andriantiana Jackie L, Mulholland Dulcie A
机构信息
Natural Products Research Group, Department of Chemistry, Faculty of Engineering and Physical Sciences, University of Surrey , Guildford, GU2 7XH, United Kingdom.
School of Life Sciences, Pharmacy and Chemistry, Faculty of Science, Engineering and Computing, Kingston University , Penrhyn Road, Kingston Upon Thames, KT1 2EE, United Kingdom.
出版信息
J Nat Prod. 2017 Jan 27;80(1):30-37. doi: 10.1021/acs.jnatprod.6b00240. Epub 2017 Jan 4.
The genus Rhodocodon (Hyacinthaceae sensu APG II) is endemic to Madagascar, and its phytochemistry has not been described previously. The phytochemistry of three species in this genus has been investigated, and eight compounds, including three bufadienolides (compounds 1, 4, and 5), a norlignan (2), and four homoisoflavonoids (compounds 3 and 6-8), have been isolated and identified. Compounds 1-3 and 6-8 have not been described previously. The COX-2 inhibitory activity of compound 6 and compound 7 acetate (compound 7A) was investigated on isolated colorectal cancer cells. Compounds 6 and 7A inhibited COX-2 by 10% and 8%, respectively, at a concentration of 12.5 μM compared to 12% for 1 mM aspirin (the positive control).
红铃花属（APG II分类系统中的风信子科）为马达加斯加岛特有属，其植物化学特征此前尚未见报道。对该属三种植物的植物化学特征进行了研究，分离并鉴定出8种化合物，包括三种蟾蜍二烯羟酸内酯（化合物1、4和5）、一种去甲木脂素（2）和四种高异黄酮（化合物3和6 - 8）。化合物1 - 3和6 - 8此前未见报道。研究了化合物6和化合物7的乙酸酯（化合物7A）对分离的结肠癌细胞的COX - 2抑制活性。在浓度为12.5 μM时，化合物6和7A对COX - 2的抑制率分别为10%和8%，而作为阳性对照的1 mM阿司匹林的抑制率为12%。
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