O'Donnell Gemma, Bucar Franz, Gibbons Simon
Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Phytochemistry. 2006 Jan;67(2):178-82. doi: 10.1016/j.phytochem.2005.10.023. Epub 2005 Dec 15.
In a project to investigate plant derived natural products from the Liliaceae with activity against fast-growing strains of mycobacteria, we have identified two new metabolites from Chlorophytum inornatum. The active principle, a new homoisoflavanone (1) was identified as 3-(4'-methoxybenzyl)-7,8-methylenedioxy-chroman-4-one. The metabolite assigned as 7-(1'-hydroxyethyl)-2-(2''-hydroxyethyl)-3,4-dihydrobenzopyran (2) was characterised by extensive 1- and 2D NMR spectroscopy. The antimycobacterial activity of this plant was mainly due to the homoisoflavonoid which exhibited minimum inhibitory values ranging from 16-256 microg/ml against four strains of fast-growing mycobacteria.
在一项研究来自百合科、具有抗快速生长分枝杆菌活性的植物源天然产物的项目中，我们从白花吊兰中鉴定出两种新的代谢产物。活性成分，一种新的高异黄酮（1）被鉴定为3-（4'-甲氧基苄基）-7,8-亚甲基二氧基-色满-4-酮。被认定为7-（1'-羟乙基）-2-（2''-羟乙基）-3,4-二氢苯并吡喃（2）的代谢产物通过广泛的一维和二维核磁共振光谱进行了表征。该植物的抗分枝杆菌活性主要归因于高异黄酮，其对四种快速生长分枝杆菌菌株的最低抑制值范围为16 - 256微克/毫升。
