Meyer Dorothy M, Brei Christina, Stecher Lynne, Much Daniela, Brunner Stefanie, Hauner Hans
From the Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Institute of Diabetes Research, Helmholtz Zentrum München, and Forschergruppe Diabetes, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Pediatr Res. 2017 May;81(5):745-751. doi: 10.1038/pr.2016.275. Epub 2017 Jan 4.
Few human studies have explored the role of adiponectin in early life on growth and adipose tissue development.
High molecular weight (HMW) and total adiponectin levels from 141 cord blood samples and plasma blood samples from 40 3-y-old children were analyzed. Associations between adiponectin levels in cord blood and child plasma, and infant/child growth and fat mass measurements up to the age of 5 y were assessed using linear regression models.
HMW cord blood adiponectin was positively associated with weight, BMI percentiles, and lean body mass at birth only. At 3 and 4 y, positive associations were found with cord blood adiponectin and sum of four skinfold thickness measures and percentage of body fat following adjustment for maternal and child covariates, but did not persist at 5 y. There was no significant evidence of an association between child plasma HMW adiponectin and growth or body composition characteristics at 3-5 y.
Our results do not support the hypothesis that HMW cord blood adiponectin is a useful biomarker for the prediction of adiposity at the age of 5 y. Additionally, there is no evidence that plasma HMW adiponectin levels predict body fat distribution between 3-5 y.
很少有人类研究探讨脂联素在生命早期对生长和脂肪组织发育的作用。
分析了141份脐带血样本和40名3岁儿童的血浆样本中的高分子量（HMW）和总脂联素水平。使用线性回归模型评估脐带血和儿童血浆中脂联素水平与5岁前婴儿/儿童生长及脂肪量测量值之间的关联。
HMW脐带血脂联素仅与出生时的体重、BMI百分位数和瘦体重呈正相关。在3岁和4岁时，在对母婴协变量进行调整后，发现脐带血脂联素与四处皮褶厚度测量值之和以及体脂百分比呈正相关，但在5岁时这种相关性不再存在。没有显著证据表明儿童血浆HMW脂联素与3至5岁时的生长或身体成分特征之间存在关联。
我们的结果不支持HMW脐带血脂联素是预测5岁时肥胖的有用生物标志物这一假设。此外，没有证据表明血浆HMW脂联素水平可预测3至5岁时的体脂分布。
