Salas-López Enid Karina, Pierdant-Pérez Mauricio, Hernández-Sierra Juan Francisco, Ruíz Facundo, Mandeville Peter, Pozos-Guillén Amaury J
J Clin Pediatr Dent. 2017;41(1):48-52. doi: 10.17796/1053-4628-41.1.48.
The objective of this study was to evaluate the effects of pit and fissure sealant mixed with silver nanoparticles on dental caries, by means of monthly measurement of fluorescence with DIAGNOdent over six months.
This study was divided in two phases: experimental and clinical. In the experimental phase, the adhesion and microleakage of the pit and fissure sealant experiment were evaluated. Two groups of 10 teeth, without serious carious lesions, were included. Conventional (group A) and silver nanoparticles (group B) were added to the pit and fissure sealant. For the clinical phase, a split-mouth study was performed on 40 children aged 6-10 years old with healthy, erupted permanent first molars. A conventional pit and fissure sealant or a silver nanoparticle-mixed sealant was randomly placed. Repeated measures analysis was performed.
Conventional sealant presented an average microleakage of 30.6%, and the silver nanoparticle-mixed sealant showed 33.6% (P=NS). A three times greater reduction in fluorescence was found in the silver nanoparticles group compared to the conventional group (P<0.05). No sex- or age-based associations were found.
The silver nanoparticle-mixed sealant reduced tooth demineralization significantly and likely increased remineralization, compared to the conventional sealant.
本研究的目的是通过在六个月内每月使用DIAGNOdent测量荧光，评估与银纳米颗粒混合的窝沟封闭剂对龋齿的影响。
本研究分为两个阶段：实验阶段和临床阶段。在实验阶段，评估窝沟封闭剂实验的附着力和微渗漏情况。纳入两组各10颗无严重龋损的牙齿。将传统材料（A组）和银纳米颗粒（B组）添加到窝沟封闭剂中。在临床阶段，对40名6至10岁、恒牙第一磨牙健康萌出的儿童进行了一项双盲研究。随机放置传统窝沟封闭剂或银纳米颗粒混合封闭剂。进行重复测量分析。
传统封闭剂的平均微渗漏率为30.6%，银纳米颗粒混合封闭剂为33.6%（P=无显著性差异）。与传统组相比，银纳米颗粒组的荧光降低了三倍（P<0.05）。未发现基于性别或年龄的关联。
与传统封闭剂相比，银纳米颗粒混合封闭剂显著降低了牙齿脱矿，并可能增加了再矿化。
