Pour P M, Kazakoff K
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha 68105.
Carcinogenesis. 1989 Nov;10(11):2015-7. doi: 10.1093/carcin/10.11.2015.
Rectal carcinogenicity of N-nitrosobis(2-oxopropyl)amine (BOP) in male MRC Wistar rats was shown to be inhibited by exogenous testosterone (T) when the hormone was given during, but not after, administration of the carcinogen. This effect was independent of the dose and frequency of BOP, which was given either weekly for 20 weeks orally or daily for 3 days subcutaneously. Since, except for prostatic cancer, the incidence and the patterns of other BOP-induced tumors were not altered by T, this hormone seems to play a specific role in the rectal carcinogenesis of BOP.
当在给予致癌物期间而非之后给予外源性睾酮（T）时，已表明其可抑制雄性MRC Wistar大鼠中N-亚硝基双（2-氧代丙基）胺（BOP）的直肠致癌性。这种作用与BOP的剂量和给药频率无关，BOP给药方式为每周口服一次，持续20周，或皮下每日注射一次，持续3天。由于除前列腺癌外，T并未改变其他BOP诱导肿瘤的发生率和模式，因此这种激素似乎在BOP的直肠致癌过程中发挥特定作用。
