Pour P
Cancer Lett. 1978 May;4(5):293-8. doi: 10.1016/s0304-3835(78)95282-5.
Weekly subcutaneous injection of 10 mg/kg body wt. of N-nitrosobis(2-oxopropyl)amine (BOP), a pancreatic carcinogen in Syrian golden hamsters, induced colorectal cancer in MRC rats in 67% of all males and 33% of all females that survived beyond 43 and 68 weeks, respectively. Tumors were concentrated in specific segments of the large bowel and not found in the small intestine. Although the distribution of cancer in the cecum, and ascending and descending colon was similar in both sexes, rectal cancer predominated significantly in males. These data and the tumor morphology indicate the present model more closely resembles the corresponding human disease than do models in previous relevant experimental studies.
每周皮下注射10毫克/千克体重的N-亚硝基双（2-氧代丙基）胺（BOP），这是叙利亚金仓鼠的一种胰腺癌致癌物，在MRC大鼠中，分别在存活超过43周和68周的所有雄性大鼠的67%和所有雌性大鼠的33%中诱发了结直肠癌。肿瘤集中在大肠的特定节段，在小肠中未发现。虽然盲肠、升结肠和降结肠中的癌症分布在两性中相似，但直肠癌在男性中显著占主导。这些数据和肿瘤形态表明，与之前相关实验研究中的模型相比，当前模型更接近相应的人类疾病。
