Suzuki Takayoshi, Masui Aya, Nakamura Jun, Shiozawa Hirokazu, Aoki Jun, Nakae Hirohiko, Tsuda Shingo, Imai Jin, Hideki Ozawa, Matsushima Masashi, Mine Tetsuya, Tamura Akira, Ohtsu Toshihiro, Asami Yukio, Takagi Atsushi
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University Tokyo Hospital, Tokyo, Japan.
Digestion. 2017;95(1):49-54. doi: 10.1159/000452361. Epub 2017 Jan 5.
Although there is evidence about the beneficial effects of probiotics, their effects on aspirin-induced small bowel injuries have not been well examined. We evaluated the effects of the probiotic Lactobacillus gasseri OLL2716 (LG) on aspirin-induced small intestinal lesions, such as ulcers, erosions, reddened lesions, and bleeding.
This study enrolled 64 patients who received aspirin for more than 1 month and provided written informed consent to be part of the study. The patients received 112 ml of yogurt containing LG or placebo twice daily for 6 weeks. Small bowel injuries were evaluated by capsule endoscopy before and after consuming the yogurt. The effect of LG on patient symptoms was also assessed using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (FSSG) and Gastrointestinal Symptom Rating Scale (GSRS) questionnaires before and after 6 weeks of treatment. There was no significant difference in any baseline characteristics and the number of small bowel mucosal breaks between the 2 groups. In contrast with the placebo group, the LG group had significantly fewer small bowel mucosal breaks and reddened lesions after 6 weeks (p < 0.01). The FSSG and GSRS scores were also significantly improved in the LG group but not in the placebo group. Key Messages: This double-blind, placebo-controlled study found that LG may be useful in reducing aspirin-induced small bowel injuries and in mitigating gastrointestinal symptoms.
尽管有证据表明益生菌具有有益作用，但其对阿司匹林所致小肠损伤的影响尚未得到充分研究。我们评估了益生菌加氏乳杆菌OLL2716（LG）对阿司匹林所致小肠病变（如溃疡、糜烂、发红病变和出血）的影响。
本研究纳入了64例服用阿司匹林超过1个月并提供书面知情同意参与研究的患者。患者每天两次接受112毫升含LG的酸奶或安慰剂，持续6周。在食用酸奶前后通过胶囊内镜评估小肠损伤情况。还在治疗6周前后使用胃食管反流病症状频率量表（FSSG）和胃肠道症状评分量表（GSRS）问卷评估LG对患者症状的影响。两组之间的任何基线特征和小肠黏膜破损数量均无显著差异。与安慰剂组相比，LG组在6周后小肠黏膜破损和发红病变明显减少（p < 0.01）。LG组的FSSG和GSRS评分也显著改善，而安慰剂组则未改善。关键信息：这项双盲、安慰剂对照研究发现，LG可能有助于减少阿司匹林所致小肠损伤并减轻胃肠道症状。
