Korn Verena, Surber Christian, Imanidis Georgios
Institute of Pharmaceutical Technology, School of Life Sciences, University of Applied Sciences and Arts Northwestern Switzerland, Muttenz, Zurich, Switzerland.
Skin Pharmacol Physiol. 2016;29(6):291-299. doi: 10.1159/000450760. Epub 2017 Jan 5.
BACKGROUND/AIMS: To determine the roughness of the surface of human skin at highly sun-exposed anatomical sites in a wide age range in order to derive consequences for sunscreen application.
The forehead, cheek, nose, shoulder, and dorsal hand of 4 age groups (0-9, 20-39, 40-59, and >60 years) were investigated by replica formation, and areal topography was determined by confocal chromatic imaging. The arithmetic mean height as a roughness parameter and the void volume of the surface profile were calculated.
Age and site had a significant effect on roughness. Both the dorsal hand and nose exhibited the greatest roughness over the age of 40, and the forehead of the youngest age group exhibited the smallest roughness. Differentiation between sites progressed with age, whereas roughness increased significantly with age for the dorsal hand and nose but not for the other sites. The void volume was smaller than the volume corresponding to the typically recommended amount of sunscreen application except for the cases of largest roughness.
Different site-age combinations show significant variation of skin surface roughness. The application of sunscreen may in some instances need to be adjusted to take into account the increased roughness of highly sun-exposed anatomical sites.
背景/目的:确定广泛年龄范围内高暴露于阳光下的人体解剖部位皮肤表面的粗糙度,以便得出防晒霜应用的相关结论。
通过复制成型法对4个年龄组(0 - 9岁、20 - 39岁、40 - 59岁和60岁以上)的前额、脸颊、鼻子、肩膀和手背进行研究,并通过共焦彩色成像确定表面形貌。计算作为粗糙度参数的算术平均高度和表面轮廓的空隙体积。
年龄和部位对粗糙度有显著影响。40岁以上人群的手背和鼻子粗糙度最大,最年轻年龄组的前额粗糙度最小。部位间的差异随年龄增长而增大,而手背和鼻子的粗糙度随年龄显著增加,其他部位则不然。除粗糙度最大的情况外,空隙体积小于通常推荐的防晒霜涂抹量对应的体积。
不同的部位 - 年龄组合显示出皮肤表面粗糙度的显著差异。在某些情况下,防晒霜的应用可能需要进行调整,以考虑高暴露于阳光下的人体解剖部位粗糙度增加的情况。