从丙肝治愈到乙肝治愈。
From HCV To HBV Cure.
作者信息
Schinazi Raymond F, Asselah Tarik
机构信息
Frances Winship Walters Professor of Pediatrics, Center for AIDS Research, Emory University School of Medicine, Atlanta, GA, USA.
Hepatology Department, UMR1149, Physiopathology and Treatment of Viral Hepatitis, Centre de Recherche sur l'Inflammation and Université Denis Diderot Paris 7, Beaujon Hospital, AP-HP, Clichy, France.
出版信息
Liver Int. 2017 Jan;37 Suppl 1(Suppl 1):73-80. doi: 10.1111/liv.13324.
Approximately 170 million people are chronically infected with HCV and 350 million are chronically infected with HBV worldwide. It is estimated that more than one million patients die from complications related to chronic viral hepatitis, mainly HCC which is one of the most frequent cancers in many countries, especially Africa, the Middle East and Asia. HCV drug development has been impressive, and this revolution led to several direct-acting antiviral agents achieving an HCV cure after only 6-12 weeks. This progress could theorically lead to HCV global elimination making HCV and its consequences a rarity. HBV research and development programs can learn from the HCV experience, to achieve an HBV functional or sterilizing cure. This review will summarize key steps which have been realized for an HCV cure, and discuss the next steps to achieve for an HCV elimination. And also, how this HCV revolution has inspired scientists and clinicians to achieve the same for HBV.
全球约有1.7亿人慢性感染丙型肝炎病毒（HCV），3.5亿人慢性感染乙型肝炎病毒（HBV）。据估计，每年有超过100万患者死于慢性病毒性肝炎相关并发症，主要是肝细胞癌（HCC），而HCC是许多国家（尤其是非洲、中东和亚洲）最常见的癌症之一。HCV药物研发取得了令人瞩目的进展，这场变革催生了几种直接抗病毒药物，仅需6至12周就能治愈HCV。从理论上讲，这一进展可能会使HCV在全球范围内被消除，从而使HCV及其后果变得罕见。HBV研发项目可以借鉴HCV的经验，实现对HBV的功能性治愈或清除性治愈。本综述将总结实现HCV治愈所取得的关键步骤，并讨论实现HCV消除的后续步骤。此外，还将探讨这场HCV变革如何激励科学家和临床医生在HBV治疗方面取得同样的成果。
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