Al-Omair Mohammed A., Sedky Azza, Ali Awatef, Elsawy Hany
Chemistry Department, College of Science, King Faisal University, Al-Ahsaa, King Saudi Arabia.
Zoology Department, Faculty of Science, Alexandria University, Alexandria, Egypt.
Chin J Physiol. 2017 Feb 28;60(1):54-61. doi: 10.4077/CJP.2017.BAF440.
Lead is one of the oldest environmental and occupational toxins. Health hazards from increased lead exposure as a result of industrial and environmental pollution are recognized. The aim of the present study was to investigate the protective effects of quercetin as a model of an antioxidant drug against the toxic effects of lead acetate on the blood and the testis of rats. The lead concentrations were determined in blood and the testis. Testosterone (T), luteinizing hormone (LH) and follicle stimulating hormone (FSH) were assessed in serum. Hemoglobin (Hb) content, packed cell volume (PCV), white blood cell (WBC) and red blood cell (RBC) counts were evaluated in the whole blood. Our results showed that administration of lead acetate was associated with an increased lead levels in blood as well as in the testis. Lead acetate administration also caused a decrease in testicular function, Hb content, PCV and RBC count in comparison to the respective mean values of the control. In addition, lead acetate increased WBC count and induced alterations in sperm count, sperm motility and sperm abnormality and histopathology. In the contrary, administration of lead acetate along with quercetin partially restored the studied parameters to normal values. In conclusion, the treatment with quercetin may provide a partial protection against the toxic effects induced by lead acetate in blood and the testis of rats.
铅是最古老的环境毒素和职业毒素之一。人们已经认识到工业和环境污染导致铅暴露增加所带来的健康危害。本研究的目的是调查槲皮素作为一种抗氧化药物模型对醋酸铅对大鼠血液和睾丸的毒性作用的保护效果。测定了血液和睾丸中的铅浓度。评估了血清中的睾酮（T）、黄体生成素（LH）和卵泡刺激素（FSH）。评估了全血中的血红蛋白（Hb）含量、血细胞比容（PCV）、白细胞（WBC）和红细胞（RBC）计数。我们的结果表明，给予醋酸铅会导致血液和睾丸中的铅水平升高。与对照组各自的平均值相比，给予醋酸铅还会导致睾丸功能、Hb含量、PCV和RBC计数下降。此外，醋酸铅会增加WBC计数，并导致精子计数、精子活力、精子异常和组织病理学改变。相反，给予醋酸铅和槲皮素可使所研究的参数部分恢复到正常水平。总之，槲皮素治疗可能对醋酸铅对大鼠血液和睾丸诱导的毒性作用提供部分保护。
