The Laboratory of Molecular Nutrition and Immunity, Institute of Animal Nutrition, Northeast Agricultural University, Harbin, People's Republic of China.
Biol Trace Elem Res. 2021 Oct;199(10):3960-3976. doi: 10.1007/s12011-020-02498-w. Epub 2020 Nov 24.
Lead is one of the most common heavy metal elements and has high biological toxicity. Long-term lead exposure will induce the contamination of animal feed, water, and food, which can cause chronic lead poisoning including nephrotoxicity, hepatotoxicity, neurotoxicity, and reproductive toxicity in humans and animals. In the past few decades, lead has caused widespread concern because of its significant threat to health. A large number of in vitro and animal experiments have shown that oxidative stress plays a key role in lead toxicity, and endoplasmic reticulum (ER) stress and the mitochondrial apoptosis pathway can also be induced by lead toxicity. Therefore, plant polyphenols have attracted attention, with their advantages of being natural antioxidants and having low toxicity. Plant polyphenols can resist lead toxicity by chelating lead with their special chemical molecular structure. In addition, scavenging active oxygen and improving the level of antioxidant enzymes, anti-inflammatory, and anti-apoptosis are also the key to relieving lead poisoning by plant polyphenols. Various plant polyphenols have been suggested to be useful in alleviating lead toxicity in animals and humans and are believed to have good application prospects.
铅是最常见的重金属元素之一，具有很高的生物毒性。长期接触铅会导致动物饲料、水和食物受到污染，从而导致人类和动物发生慢性铅中毒，包括肾毒性、肝毒性、神经毒性和生殖毒性。在过去的几十年中，由于铅对健康的重大威胁，它引起了广泛的关注。大量的体外和动物实验表明，氧化应激在铅毒性中起着关键作用，铅毒性还可以诱导内质网（ER）应激和线粒体凋亡途径。因此，植物多酚因其天然抗氧化剂和低毒性的优势而受到关注。植物多酚可以通过其特殊的化学分子结构与铅螯合来抵抗铅毒性。此外，清除活性氧和提高抗氧化酶水平、抗炎和抗细胞凋亡也是植物多酚缓解铅中毒的关键。各种植物多酚已被证明对缓解动物和人类的铅毒性有效，被认为具有良好的应用前景。
