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在危及生命的快速性心律失常动物模型中的经食管低能量心脏复律

Transesophageal low-energy cardioversion in an animal model of life-threatening tachyarrhythmias.

作者信息

Cai Y C, Fan S L, Feng D X, Gan S X, Feng J F, Kuang Z S, Li Z F

机构信息

Guizhou Provincial Cardiovascular Institute, Republic of China.

出版信息

Circulation. 1989 Nov;80(5):1354-9. doi: 10.1161/01.cir.80.5.1354.

Abstract

The purpose of this study was to determine the feasibility and efficacy of terminating life-threatening ventricular tachyarrhythmia by low-energy synchronous or asynchronous shocks delivered through a transesophageal catheter that had both an anode and a cathode. Forty-three episodes of ventricular fibrillation or flutter (Vf or VF) were provoked by transesophageal asynchronous random shocks occurring during the vulnerable period of the ventricular cycle in seven dogs and seven pigs that were healthy adults. The 43 episodes of Vf or VF were terminated by the transesophageal technique. The defibrillation energy thresholds were 23.11 +/- 6.28 J (range, 5-30 J). Seven episodes of ventricular tachycardia (VT) with a cycle length of 360 msec or less (330 +/- 27 msec) were provoked by ventricular pacing stimuli during acute myocardial ischemia resulting from delayed resuscitation in two dogs and three pigs. Five of the seven VTs had a duration of 31 seconds or more, and they were all terminated by transesophageal synchronous shocks, the cardioversion thresholds being 1.71 +/- 2.25 J (range, 0.25-5 J). Fourteen episodes of idioventricular tachycardia (IVT) with a cycle length of 400 msec or more (445 +/- 33.5 msec) spontaneously occurred after the use of adrenaline and after defibrillation in four dogs and five pigs. We also succeeded in terminating seven episodes of IVT with a duration of 34 seconds or more by the same means of treating VT, although IVT is not an indication for cardioversion in the clinical setting.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

本研究的目的是确定通过经食管导管(该导管同时具有阳极和阴极)输送低能量同步或非同步电击来终止危及生命的室性快速心律失常的可行性和有效性。在7只健康成年犬和7只猪的心室周期易损期,通过经食管非同步随机电击诱发了43次室颤或室扑(Vf或VF)发作。这43次Vf或VF发作均通过经食管技术终止。除颤能量阈值为23.11±6.28 J(范围为5 - 30 J)。在两只犬和三只猪因复苏延迟导致急性心肌缺血期间,通过心室起搏刺激诱发了7次周期长度为360毫秒或更短(330±27毫秒)的室性心动过速(VT)。7次VT中有5次持续时间为31秒或更长,它们均通过经食管同步电击终止,转复阈值为1.71±2.25 J(范围为0.25 - 5 J)。在4只犬和5只猪使用肾上腺素及除颤后,自发出现了14次周期长度为400毫秒或更长(445±33.5毫秒)的心室自主节律性心动过速(IVT)。我们还通过与治疗VT相同的方法成功终止了7次持续时间为34秒或更长的IVT发作,尽管在临床环境中IVT并非转复的适应证。(摘要截断于250字)

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