高剂量氨苄西林-舒巴坦组合在中空纤维感染模型中对抗多粘菌素耐药鲍曼不动杆菌
High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model.
作者信息
Lenhard Justin R, Smith Nicholas M, Bulman Zackery P, Tao Xun, Thamlikitkul Visanu, Shin Beom S, Nation Roger L, Li Jian, Bulitta Jürgen B, Tsuji Brian T
机构信息
Laboratory for Antimicrobial Dynamics, NYS Center of Excellence in Bioinformatics & Life Sciences, Buffalo, New York, USA.
School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, New York, USA.
出版信息
Antimicrob Agents Chemother. 2017 Feb 23;61(3). doi: 10.1128/AAC.01268-16. Print 2017 Mar.
Abstract
is emerging with resistance to polymyxins. In 24-h time-kill experiments, high-dose ampicillin-sulbactam in combination with meropenem and polymyxin B achieved additivity or synergy against 10 CFU/ml of two clinical isolates resistant to all three drugs (maximum reductions, 1.6 and 3.1 logs). In a 14-day hollow-fiber infection model, high-dose ampicillin-sulbactam (8/4 g every 8 h, respectively) in combination with meropenem (2 g every 8 h) and polymyxin B (1.43 mg/kg of body weight every 12 h with loading dose) resulted in rapid (96 h) eradication of .
摘要
对多粘菌素产生耐药性的情况正在出现。在24小时杀菌试验中，高剂量氨苄西林-舒巴坦联合美罗培南和多粘菌素B对每毫升10菌落形成单位的两种对所有三种药物耐药的临床分离株具有相加或协同作用（最大降低量分别为1.6和3.1个对数）。在14天的中空纤维感染模型中，高剂量氨苄西林-舒巴坦（分别为每8小时8/4克）联合美罗培南（每8小时2克）和多粘菌素B（每12小时1.43毫克/千克体重，负荷剂量）导致迅速（96小时）清除……
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