Ford H C, Crooke M J, Murphy C E
Department of Laboratory Services, Wellington Hospital, New Zealand.
Clin Biochem. 1989 Oct;22(5):373-6. doi: 10.1016/s0009-9120(89)80035-9.
The concentrations in serum of total and ionised calcium, phosphate, magnesium, albumin and alkaline phosphatase activity were measured in patients when hyperthyroid and again when euthyroid. Significant declines in the mean values of ionised calcium, phosphate and alkaline phosphatase activity and significant increases in the mean concentrations of magnesium and albumin were observed. Similar changes were observed in most individual patients. Levels of ionised calcium greater than two standard deviations (representing between batch imprecision) above the upper limit of the reference range were present in 15.6% of hyperthyroid patients. The hyperthyroid levels of calcium, ionised calcium and alkaline phosphatase activity were highest in patients with the most severe thyrotoxicosis. Disturbances of calcium and magnesium metabolism are frequent in hyperthyroid patients.
对甲状腺功能亢进患者及其甲状腺功能正常时的血清总钙、离子钙、磷酸盐、镁、白蛋白浓度以及碱性磷酸酶活性进行了测量。结果观察到离子钙、磷酸盐和碱性磷酸酶活性的平均值显著下降，而镁和白蛋白的平均浓度显著升高。大多数个体患者也观察到了类似的变化。15.6%的甲状腺功能亢进患者离子钙水平高于参考范围上限两个标准差（代表批间不精密度）。在甲状腺毒症最严重的患者中，钙、离子钙和碱性磷酸酶活性的甲状腺功能亢进水平最高。甲状腺功能亢进患者常出现钙和镁代谢紊乱。
