Chen Yi-Ting, Su Kuan-Pin, Chang Jane Pei-Chen
Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan.
Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan; School of Medicine, China Medical University, Taichung, Taiwan; Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan; Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Neuropsychiatr Dis Treat. 2016 Dec 21;13:35-40. doi: 10.2147/NDT.S118902. eCollection 2017.
A 17-year-old adolescent boy presented with atypical major depressive episode (MDE) without specific focal neurological signs for 6 months. He had a diagnosis of intra-cranial germinoma, and the atypical MDE symptoms subsided after the operation. However, he had a relapse of atypical MDE 7 months after the first surgery. His mood and binge eating symptoms subsided, but intractable body weight gain only partially improved after treatment. When encountering manifestations of depression with atypical features, especially with binge eating symptoms in male children and adolescents, with early onset age, no family history, and prolonged depressive episodes, clinicians should consider not only mood disorders including bipolar spectrum disorders but also organic brain lesions such as intracranial germinoma.
一名17岁的青少年男性出现非典型重度抑郁发作（MDE）6个月，无特定局灶性神经体征。他被诊断为颅内生殖细胞瘤，手术后非典型MDE症状消退。然而，首次手术后7个月，他的非典型MDE复发。他的情绪和暴饮暴食症状消退，但治疗后难以控制的体重增加仅部分改善。当遇到具有非典型特征的抑郁表现时，尤其是在男性儿童和青少年中伴有暴饮暴食症状、起病年龄早、无家族史且抑郁发作持续时间长时，临床医生不仅应考虑包括双相谱系障碍在内的情绪障碍，还应考虑颅内生殖细胞瘤等器质性脑病变。
