• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脐带间充质干细胞通过线粒体转移抑制系统性红斑狼疮患者T细胞的自噬

Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.

作者信息

Chen Jinyun, Wang Qian, Feng Xuebing, Zhang Zhuoya, Geng Linyu, Xu Ting, Wang Dandan, Sun Lingyun

机构信息

Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, China.

Department of Rheumatology and Immunology, Drum Tower Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu 210008, China.

出版信息

Stem Cells Int. 2016;2016:4062789. doi: 10.1155/2016/4062789. Epub 2016 Dec 7.

DOI:10.1155/2016/4062789
PMID:28053607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5174187/
Abstract

Aberrant autophagy played an important role in the pathogenesis of autoimmune diseases, especially in systemic lupus erythematosus (SLE). In this study, we showed that T cells from SLE patients had higher autophagic activity than that from healthy controls. A correlation between autophagic activity and apoptotic rate was observed in activated T cells. Moreover, activation of autophagy with rapamycin increased T cell apoptosis, whereas inhibition of autophagy with 3-MA decreased T cell apoptosis. Umbilical cord-derived mesenchymal stem cells (UC-MSCs) could inhibit respiratory mitochondrial biogenesis in activated T cells to downregulate autophagy and consequently decrease T cell apoptosis through mitochondrial transfer and thus may play an important role in SLE treatment.

摘要

异常自噬在自身免疫性疾病的发病机制中起重要作用，尤其是在系统性红斑狼疮（SLE）中。在本研究中，我们发现SLE患者的T细胞自噬活性高于健康对照者。在活化的T细胞中观察到自噬活性与凋亡率之间存在相关性。此外，用雷帕霉素激活自噬可增加T细胞凋亡，而用3-甲基腺嘌呤抑制自噬则可降低T细胞凋亡。脐带间充质干细胞（UC-MSC）可抑制活化T细胞中的呼吸线粒体生物合成，以下调自噬，从而通过线粒体转移减少T细胞凋亡，因此可能在SLE治疗中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/ec40ae47995e/SCI2016-4062789.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/09f0cef009a9/SCI2016-4062789.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/cd132276d915/SCI2016-4062789.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/18ba7ca98015/SCI2016-4062789.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/b1ba99fb4e3a/SCI2016-4062789.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/e5a6cc8a7109/SCI2016-4062789.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/8865627a73bd/SCI2016-4062789.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/5195b11ac70e/SCI2016-4062789.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/ec40ae47995e/SCI2016-4062789.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/09f0cef009a9/SCI2016-4062789.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/cd132276d915/SCI2016-4062789.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/18ba7ca98015/SCI2016-4062789.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/b1ba99fb4e3a/SCI2016-4062789.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/e5a6cc8a7109/SCI2016-4062789.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/8865627a73bd/SCI2016-4062789.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/5195b11ac70e/SCI2016-4062789.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d59/5174187/ec40ae47995e/SCI2016-4062789.008.jpg

相似文献

1
Umbilical Cord-Derived Mesenchymal Stem Cells Suppress Autophagy of T Cells in Patients with Systemic Lupus Erythematosus via Transfer of Mitochondria.脐带间充质干细胞通过线粒体转移抑制系统性红斑狼疮患者T细胞的自噬
Stem Cells Int. 2016;2016:4062789. doi: 10.1155/2016/4062789. Epub 2016 Dec 7.
2
Serum IFN-γ Predicts the Therapeutic Effect of Mesenchymal Stem Cells Transplantation in Systemic Lupus Erythematosus Patients.血清 IFN-γ 可预测间充质干细胞移植治疗系统性红斑狼疮患者的疗效。
Stem Cells Transl Med. 2017 Sep;6(9):1777-1785. doi: 10.1002/sctm.17-0002. Epub 2017 Jul 29.
3
Double-Edged Effect of Hydroxychloroquine on Human Umbilical Cord-Derived Mesenchymal Stem Cells Treating Lupus Nephritis in MRL/lpr Mice.羟氯喹对人脐带间充质干细胞治疗 MRL/lpr 狼疮肾炎的双刃剑效应。
Mol Pharm. 2018 May 7;15(5):1800-1813. doi: 10.1021/acs.molpharmaceut.7b01146. Epub 2018 Apr 25.
4
Human umbilical cord derived mesenchymal stem cells promote interleukin-17 production from human peripheral blood mononuclear cells of healthy donors and systemic lupus erythematosus patients.人脐带间充质干细胞促进健康供体和系统性红斑狼疮患者外周血单个核细胞产生白细胞介素-17
Clin Exp Immunol. 2016 Mar;183(3):389-96. doi: 10.1111/cei.12737. Epub 2015 Dec 16.
5
Clearance of apoptotic cells by mesenchymal stem cells contributes to immunosuppression via PGE2.间充质干细胞清除凋亡细胞通过 PGE2 发挥免疫抑制作用。
EBioMedicine. 2019 Jul;45:341-350. doi: 10.1016/j.ebiom.2019.06.016. Epub 2019 Jun 24.
6
Mesenchymal stem cells upregulate Treg cells via sHLA-G in SLE patients.间充质干细胞通过可溶性 HLA-G 上调系统性红斑狼疮患者的调节性 T 细胞。
Int Immunopharmacol. 2017 Mar;44:234-241. doi: 10.1016/j.intimp.2017.01.024. Epub 2017 Jan 25.
7
[Mechanism of umbilical cord mesenchymal stem cells in the up-regulation of regulatory T cells by transforming growth factor β1 in systemic lupus erythematosus].[脐带间充质干细胞在系统性红斑狼疮中通过转化生长因子β1上调调节性T细胞的机制]
Zhonghua Yi Xue Za Zhi. 2013 Apr 2;93(13):980-3.
8
Human umbilical cord mesenchymal stem cells derived exosomes exert antiapoptosis effect via activating PI3K/Akt/mTOR pathway on H9C2 cells.人脐带间充质干细胞来源的外泌体通过激活 PI3K/Akt/mTOR 通路对 H9C2 细胞发挥抗细胞凋亡作用。
J Cell Biochem. 2019 Sep;120(9):14455-14464. doi: 10.1002/jcb.28705. Epub 2019 Apr 15.
9
The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus.间充质干细胞对人类系统性红斑狼疮中Treg/Th17平衡的调节作用
Cell Mol Immunol. 2017 May;14(5):423-431. doi: 10.1038/cmi.2015.89. Epub 2015 Oct 5.
10
Mesenchymal stem cells induced CD4+ T cell apoptosis in treatment of lupus mice.间充质干细胞诱导 CD4+T 细胞凋亡治疗狼疮小鼠。
Biochem Biophys Res Commun. 2018 Dec 9;507(1-4):30-35. doi: 10.1016/j.bbrc.2018.10.133. Epub 2018 Nov 5.

引用本文的文献

1
Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies.间充质干细胞在治疗人类疾病中的应用：分子机制与临床研究
Signal Transduct Target Ther. 2025 Aug 22;10(1):262. doi: 10.1038/s41392-025-02313-9.
2
Adipose-derived stem cells attenuate rheumatoid arthritis by restoring CXCR1 synovial lining macrophage barrier.脂肪来源干细胞通过恢复CXCR1滑膜衬里巨噬细胞屏障减轻类风湿性关节炎。
Stem Cell Res Ther. 2025 Mar 5;16(1):111. doi: 10.1186/s13287-025-04144-5.
3
Impact of G1 phase kinetics on the acquisition of stemness in cancer cells: the critical role of cyclin D.

本文引用的文献

1
Update on mesenchymal stem cell-based therapy in lupus and scleroderma.狼疮和硬皮病中基于间充质干细胞治疗的最新进展。
Arthritis Res Ther. 2015 Nov 3;17:301. doi: 10.1186/s13075-015-0819-7.
2
The regulation of the Treg/Th17 balance by mesenchymal stem cells in human systemic lupus erythematosus.间充质干细胞对人类系统性红斑狼疮中Treg/Th17平衡的调节作用
Cell Mol Immunol. 2017 May;14(5):423-431. doi: 10.1038/cmi.2015.89. Epub 2015 Oct 5.
3
The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble.
G1期动力学对癌细胞干性获得的影响：细胞周期蛋白D的关键作用。
Mol Biol Rep. 2025 Feb 14;52(1):230. doi: 10.1007/s11033-025-10351-3.
4
The multifaceted roles of cathepsins in immune and inflammatory responses: implications for cancer therapy, autoimmune diseases, and infectious diseases.组织蛋白酶在免疫和炎症反应中的多方面作用：对癌症治疗、自身免疫性疾病和传染病的影响。
Biomark Res. 2024 Dec 31;12(1):165. doi: 10.1186/s40364-024-00711-9.
5
Re-establishing immune tolerance in multiple sclerosis: focusing on novel mechanisms of mesenchymal stem cell regulation of Th17/Treg balance.多发性硬化症中免疫耐受的重建：聚焦于间充质干细胞调节 Th17/Treg 平衡的新机制。
J Transl Med. 2024 Jul 15;22(1):663. doi: 10.1186/s12967-024-05450-x.
6
The effect of adipose-derived mesenchymal stem cell transplantation on ovarian mitochondrial dysfunction in letrozole-induced polycystic ovary syndrome in rats: the role of PI3K-AKT signaling pathway.脂肪间充质干细胞移植对来曲唑诱导的多囊卵巢综合征大鼠卵巢线粒体功能障碍的影响：PI3K-AKT 信号通路的作用。
J Ovarian Res. 2024 Apr 27;17(1):91. doi: 10.1186/s13048-024-01422-3.
7
Amelioration of diabetic nephropathy in mice by a single intravenous injection of human mesenchymal stromal cells at early and later disease stages is associated with restoration of autophagy.单次静脉注射人间质基质细胞可改善早期和晚期疾病阶段的糖尿病肾病小鼠的病情，其机制与自噬的恢复有关。
Stem Cell Res Ther. 2024 Mar 5;15(1):66. doi: 10.1186/s13287-024-03647-x.
8
Mesenchymal stem cells and connective tissue diseases: From bench to bedside.间充质干细胞与结缔组织病：从实验室到临床
J Transl Int Med. 2022 Nov 15;11(1):30-45. doi: 10.2478/jtim-2022-0028. eCollection 2023 Mar.
9
Immunomodulatory effects of umbilical mesenchymal stem cell-derived exosomes on CD4 T cells in patients with primary Sjögren's syndrome.脐带间充质干细胞来源的外泌体对原发性干燥综合征患者 CD4 T 细胞的免疫调节作用。
Inflammopharmacology. 2023 Aug;31(4):1823-1838. doi: 10.1007/s10787-023-01189-x. Epub 2023 Apr 3.
10
The Pathophysiological Significance of "Mitochondrial Ejection" from Cells.细胞中线粒体“排出”的病理生理学意义。
Biomolecules. 2022 Nov 28;12(12):1770. doi: 10.3390/biom12121770.
线粒体动力学-线粒体自噬-细胞死亡相互作用组：线粒体分子复合体成员发挥的多种作用
Circ Res. 2015 Jan 2;116(1):167-82. doi: 10.1161/CIRCRESAHA.116.303554. Epub 2014 Oct 16.
4
Restored immunosuppressive effect of mesenchymal stem cells on B cells after olfactory 1/early B cell factor-associated zinc-finger protein down-regulation in patients with systemic lupus erythematosus.恢复骨髓间充质干细胞对系统性红斑狼疮患者嗅球/早期 B 细胞因子相关锌指蛋白下调后 B 细胞的免疫抑制作用。
Arthritis Rheumatol. 2014 Dec;66(12):3413-23. doi: 10.1002/art.38879.
5
Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation.血小板释放线粒体，作为杀菌性IIA组分泌型磷脂酶A2的底物，以促进炎症反应。
Blood. 2014 Oct 2;124(14):2173-83. doi: 10.1182/blood-2014-05-573543. Epub 2014 Jul 31.
6
Autophagy promotes resistance to photodynamic therapy-induced apoptosis selectively in colorectal cancer stem-like cells.自噬选择性地促进结直肠癌干细胞样细胞对光动力疗法诱导的凋亡产生抗性。
Autophagy. 2014 Jul;10(7):1179-92. doi: 10.4161/auto.28679. Epub 2014 Apr 29.
7
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.CD8 T 细胞/吲哚胺 2,3-双加氧酶轴对于间充质干细胞抑制人系统性红斑狼疮是必需的。
Arthritis Rheumatol. 2014 Aug;66(8):2234-45. doi: 10.1002/art.38674.
8
Miro1: new wheels for transferring mitochondria.Miro1：线粒体转移的新轮子。
EMBO J. 2014 May 2;33(9):939-41. doi: 10.1002/embj.201488441. Epub 2014 Apr 7.
9
Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study.脐带间充质干细胞移植治疗活动期及难治性系统性红斑狼疮：一项多中心临床研究
Arthritis Res Ther. 2014 Mar 25;16(2):R79. doi: 10.1186/ar4520.
10
Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy.Miro1 调节细胞间线粒体运输并增强间充质干细胞的治疗效果。
EMBO J. 2014 May 2;33(9):994-1010. doi: 10.1002/embj.201386030. Epub 2014 Jan 15.