Choi Hwa-Jung
Department of Beauty Science, Kwangju Women's University, Gwangju, Korea.
Osong Public Health Res Perspect. 2016 Dec;7(6):400-403. doi: 10.1016/j.phrp.2016.11.003. Epub 2016 Nov 12.
Human rhinoviruses and enteroviruses (family Picornaviridae) infect millions of people worldwide each year, but little is known about effective therapeutical treatment for the infection caused by these viruses. We sought to determine whether or not (Rutaceae) species can exhibit antiviral activity against picornaviruses. The leaf parts of four species were extracted with methanol, and the extracts were investigated for their antiviral activity against picornaviruses using cytopathic effects by cytopathic effect reduction. Leaf extracts of among four species were found to possess only broad-spectrum antipicornavirus activity against human rhninovirus 2 with a 50% inhibitory concentration (IC) value of 59.48 μg/mL, human rhinovirus 3 with an IC value of 39.94 μg/mL, coxsackie A16 virus with an IC value of 45.80 μg/mL, coxsackie B3 virus with an IC value of 68.53 μg/mL, coxsackie B4 virus with an IC value of 93.58 μg/mL, and enterovirus 71 virus with an IC value of 4.48 μg/mL. However, ribavirin did not possess antiviral activity against human rhinovirus 3 and four enteroviruses. Therefore, leaves of showed broad-spectrum antipicornavirus activity, and may be useful as a candidate for studying picornavirus agents and development of pharmaceuticals.
人鼻病毒和肠道病毒（微小核糖核酸病毒科）每年在全球感染数百万人，但对于这些病毒引起的感染的有效治疗方法知之甚少。我们试图确定芸香科植物是否能对微小核糖核酸病毒表现出抗病毒活性。用甲醇提取了四种芸香科植物的叶片部分，并通过细胞病变效应减少法研究了提取物对微小核糖核酸病毒的抗病毒活性。在四种芸香科植物中，发现某一植物的叶片提取物仅对人鼻病毒2具有广谱抗微小核糖核酸病毒活性，其50%抑制浓度（IC）值为59.48μg/mL，对人鼻病毒3的IC值为39.94μg/mL，对柯萨奇A16病毒的IC值为45.80μg/mL，对柯萨奇B3病毒的IC值为68.53μg/mL，对柯萨奇B4病毒的IC值为93.58μg/mL，对肠道病毒71的IC值为4.48μg/mL。然而，利巴韦林对人鼻病毒3和四种肠道病毒没有抗病毒活性。因此，某一植物的叶子表现出广谱抗微小核糖核酸病毒活性，可能作为研究微小核糖核酸病毒制剂和开发药物的候选物。 （注：原文中部分“ ”表述不清楚，这里按推测翻译，可能影响准确性）
