来自澳洲腊菊的腊菊酸对小核糖核酸病毒的抗病毒活性。

Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses.

作者信息

Choi H J, Lim C H, Song J H, Baek S H, Kwon D H

机构信息

Natural Medicines Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-333, Republic of Korea.

出版信息

Phytomedicine. 2009 Jan;16(1):35-9. doi: 10.1016/j.phymed.2008.10.012. Epub 2008 Dec 20.

DOI:10.1016/j.phymed.2008.10.012

PMID:19097770

Abstract

RNA viruses are a major source of respiratory diseases worldwide. The lack of effective therapeutical treatment underlines the importance of research for new antiviral compounds. Raoulic acid is a principal ingredient of the plant Raoulia australis Hook. F. Antiviral assay using cytopathic effect (CPE) reduction method showed that raoulic acid possessed strong antiviral activity against human rhinovirus 2 (HRV2) with a 50% inhibition concentration (IC(50)) value of less than 0.1mug/ml, human rhinovirus 3 (HRV3) with a IC(50) value of 0.19 microg/ml, coxsackie B3 (CB3) virus with IC(50) values of 0.33 microg/ml, coxsackie B4 (CB4) virus with IC(50) values of 0.40 microg/ml, and enterovirus 71 (EV71) virus with IC(50) values of less than 0.1 microg/ml. However, the compound did not possess antiviral activity against influenza A (Flu A/PR, Flu A/WS, H1N1) and B viruses at four concentrations ranging from 0.1 to 100 microg/ml.

摘要

RNA病毒是全球范围内呼吸道疾病的主要来源。缺乏有效的治疗方法凸显了研发新型抗病毒化合物的重要性。拉乌尔酸是植物南方拉乌尔菊（Raoulia australis Hook. F.）的主要成分。采用细胞病变效应（CPE）降低法进行的抗病毒试验表明，拉乌尔酸对人鼻病毒2型（HRV2）具有强大的抗病毒活性，其50%抑制浓度（IC50）值小于0.1μg/ml；对人鼻病毒3型（HRV3）的IC50值为0.19μg/ml；对柯萨奇B3（CB3）病毒的IC50值为0.33μg/ml；对柯萨奇B4（CB4）病毒的IC50值为0.40μg/ml；对肠道病毒71型（EV71）病毒的IC50值小于0.1μg/ml。然而，在0.1至100μg/ml的四个浓度下，该化合物对甲型流感病毒（Flu A/PR、Flu A/WS、H1N1）和乙型流感病毒均无抗病毒活性。