Cyr61表达数据的概况与银屑病中的皮肤炎症相关。
The profile of Cyr61 expression data correlate to the skin inflammation in psoriasis.
作者信息
Wu Pinru, Ma Gang, Li Ningli
机构信息
Shanghai Institute of Immunology, Institute of Medical science, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Dermatology, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People׳s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Data Brief. 2016 Dec 15;10:487-491. doi: 10.1016/j.dib.2016.12.008. eCollection 2017 Feb.
The data presented in this article are related to the research article entitled "Cyr61/CCN1 is involved in the pathogenesis of psoriasis vulgaris via promoting IL-8 production by keratinocytes in a JNK/NF-κB pathway" (Pinru Wu, Gang Ma, Xianjin Zhu, Ting Gu, Jie Zhang, Yue Sun, Hui Xu, Rongfen Huo, Beiqing Wang, Baihua Shen, Xiangdong Chen, Ningli Li, 2016) [1]. Cysteine-rich 61 (Cyr61/CCN1), a secreted extracellular matrix protein, is a novel proinflammatory factor. In this dataset skin samples from normal donors and psoriasis vulgaris patients were examined the expression of Cyr61 and IL-8 using immunohistochemistry. IMQ-induced psoriasis-like mice were treated with anti-Cyr61monoclonal antibodies (mAb).
本文呈现的数据与题为《Cyr61/CCN1通过JNK/NF-κB途径促进角质形成细胞产生IL-8参与寻常型银屑病的发病机制》的研究文章相关（吴品如、马刚、朱先进、顾婷、张杰、孙悦、徐辉、霍荣芬、王北清、沈百花、陈向东、李宁丽，2016年）[1]。富含半胱氨酸的61（Cyr61/CCN1）是一种分泌型细胞外基质蛋白，是一种新型促炎因子。在该数据集中，使用免疫组织化学检测了正常供体和寻常型银屑病患者皮肤样本中Cyr61和IL-8的表达。用抗Cyr61单克隆抗体（mAb）处理咪喹莫特诱导的银屑病样小鼠。
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