La Joie Renaud, Perrotin Audrey, Egret Stéphanie, Pasquier Florence, Tomadesso Clémence, Mézenge Florence, Desgranges Béatrice, de La Sayette Vincent, Chételat Gaël
INSERM, U1077, Caen, France; Université de Caen Normandie, UMR-S1077, Caen, France; Ecole Pratique des Hautes Etudes, UMR-S1077, Caen, France; CHU de Caen, U1077, Caen, France.
Department of Neurology, Memory Research and Resources Clinic, University Hospital of Lille, Lille, France; Université de Lille Nord de France, Lille, France.
Alzheimers Dement (Amst). 2016 Dec 18;5:23-34. doi: 10.1016/j.dadm.2016.12.005. eCollection 2016.
Subjective cognitive decline (SCD) could help identify early stages of Alzheimer's disease. However, SCD is multidetermined and protean, and the type of cognitive complaint associated with preclinical Alzheimer's disease needs refinement.
A total of 185 nondemented elders recruited from either the community or from a memory clinic filled a questionnaire. We searched for item responses associated with medical help seeking, cognitive deficits, and β-amyloidosis.
Compared with community-recruited control subjects ( = 74), help-seeking patients reported a stronger multidomain SCD that was mostly unrelated to the presence of detectable cognitive deficits. Only a few items, notably assessing temporal disorientation, distinguished help-seeking patients with ( = 78) or without ( = 33) memory deficits. Associations between SCD and β-amyloidosis were not restricted to the memory domain and varied across clinical stages.
Detailed evaluation of SCD could provide accessible indication of the presence of β-amyloid or cognitive deficits, which might prove useful for early diagnosis and clinical trial enrichment strategies.
主观认知下降（SCD）有助于识别阿尔茨海默病的早期阶段。然而，SCD是多因素决定且形式多样的，与临床前阿尔茨海默病相关的认知主诉类型需要细化。
从社区或记忆诊所招募的185名无痴呆的老年人填写了一份问卷。我们寻找与寻求医疗帮助、认知缺陷和β淀粉样病变相关的项目反应。
与社区招募的对照受试者（n = 74）相比，寻求帮助的患者报告了更强的多领域SCD，这大多与可检测到的认知缺陷的存在无关。只有少数项目，特别是评估时间定向障碍的项目，能区分有记忆缺陷（n = 78）或无记忆缺陷（n = 33）的寻求帮助的患者。SCD与β淀粉样病变之间的关联不限于记忆领域，且在不同临床阶段有所不同。
对SCD的详细评估可以提供β淀粉样蛋白或认知缺陷存在的可及指标，这可能对早期诊断和临床试验富集策略有用。
