Bossola Maurizio, Di Stasio Enrico, Antocicco Manuela, Pepe Gilda, Marzetti Emanuele, Vulpio Carlo
Hemodialysis Unit, Institute of Clinical Surgery, Catholic University of the Sacred Heart, Rome, Italy.
Department of Clinical Chemistry, Catholic University of the Sacred Heart, Rome, Italy.
Int Urol Nephrol. 2017 Apr;49(4):727-734. doi: 10.1007/s11255-016-1496-4. Epub 2017 Jan 4.
Fatigue is common in end-stage renal disease patients receiving hemodialysis, reduces significantly their quality of life and is associated with all-cause and cardiac-related mortality. Unfortunately, little is known about the course of fatigue in patients on chronic hemodialysis.
The Vitality Subscale of the SF-36 (SF-36 VS), Short-Form Health Survey, was administered to 45 patients in January (T1), June (T2) and November (T3) 2015.
The score of the SF-36 VS did not differ significantly among T1, T2 and T3. Similarly, the 1-year course of the SF-36 Vitality Subscale score did not differ significantly among T1, T2 and T3 after stratification of patients for sex, age, BMI, IADL and Charlson. Between T1 and T2, 21 out of 45 patients (46.6%) changed their fatigue status: 8 fatigued patients became not-fatigued and 13 not-fatigued patients became fatigued. Between T2 and T3, 12 out of 45 (26.6%) patients changed their fatigue status: 5 fatigued patients became not-fatigued and 7 not-fatigued patients became fatigued. Between T1 and T3, 19 out of 45 patients (42.2%) changed their fatigue status: 6 fatigued patients became not-fatigued and 13 not-fatigued became fatigued.
The present study is the first to identify variations in fatigue status among patients on chronic hemodialysis during 1-year course. These findings suggest to frequently assess the presence and severity of fatigue in patients on chronic hemodialysis.
疲劳在接受血液透析的终末期肾病患者中很常见,会显著降低他们的生活质量,并与全因死亡率和心脏相关死亡率相关。不幸的是,对于慢性血液透析患者疲劳的病程了解甚少。
2015年1月(T1)、6月(T2)和11月(T3),对45名患者进行了简短健康调查问卷SF-36的活力子量表(SF-36 VS)评估。
T1、T2和T3之间SF-36 VS的得分无显著差异。同样,在根据性别、年龄、体重指数、日常生活活动能力和查尔森合并症指数对患者进行分层后,T1、T2和T3之间SF-36活力子量表得分的1年病程也无显著差异。在T1和T2之间,45名患者中有21名(46.6%)改变了他们的疲劳状态:8名疲劳患者变得不疲劳,13名不疲劳患者变得疲劳。在T2和T3之间,45名患者中有12名(26.6%)改变了他们的疲劳状态:5名疲劳患者变得不疲劳,7名不疲劳患者变得疲劳。在T1和T3之间,45名患者中有19名(42.2%)改变了他们的疲劳状态:6名疲劳患者变得不疲劳,13名不疲劳患者变得疲劳。
本研究首次发现了慢性血液透析患者在1年病程中疲劳状态的变化。这些发现提示应经常评估慢性血液透析患者疲劳的存在情况和严重程度。