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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Zhan C Y, Tang F, Lee A Y, Wong T M

Department of Physiology, University of Hong Kong.

Clin Exp Pharmacol Physiol. 1989 Jul;16(7):591-6. doi: 10.1111/j.1440-1681.1989.tb01609.x.

The effects of reserpine treatment on the myocardial contents of catecholamines and enkephalins and the incidence of ventricular arrhythmias during ischaemia and reperfusion in the isolated rat heart were studied. 2. Reserpine treatment almost completely depleted the heart of noradrenaline (NA). It also significantly depleted the heart of adrenaline and dopamines. It did not, however, alter the myocardial contents of enkephalins. 3. Reserpine-treatment attenuated significantly, but did not abolish, cardiac arrhythmias induced by ischaemia and reperfusion in the isolated heart preparation. 4. The results of the present study indicate that myocardial catecholamines especially NA are a contributing factor to arrhythmogenesis during ischaemia and reperfusion.

研究了利血平处理对离体大鼠心脏缺血及再灌注过程中儿茶酚胺和脑啡肽心肌含量以及室性心律失常发生率的影响。2. 利血平处理几乎完全耗尽了心脏中的去甲肾上腺素（NA）。它还显著耗尽了心脏中的肾上腺素和多巴胺。然而，它并未改变脑啡肽的心肌含量。3. 利血平处理显著减轻但并未消除离体心脏制剂中由缺血和再灌注诱导的心律失常。4. 本研究结果表明，心肌儿茶酚胺尤其是NA是缺血和再灌注期间心律失常发生的一个促成因素。

Zhan C Y, Tang F, Lee A Y, Wong T M

Department of Physiology, University of Hong Kong.

Clin Exp Pharmacol Physiol. 1989 Jul;16(7):591-6. doi: 10.1111/j.1440-1681.1989.tb01609.x.

The effects of reserpine treatment on the myocardial contents of catecholamines and enkephalins and the incidence of ventricular arrhythmias during ischaemia and reperfusion in the isolated rat heart were studied. 2. Reserpine treatment almost completely depleted the heart of noradrenaline (NA). It also significantly depleted the heart of adrenaline and dopamines. It did not, however, alter the myocardial contents of enkephalins. 3. Reserpine-treatment attenuated significantly, but did not abolish, cardiac arrhythmias induced by ischaemia and reperfusion in the isolated heart preparation. 4. The results of the present study indicate that myocardial catecholamines especially NA are a contributing factor to arrhythmogenesis during ischaemia and reperfusion.

研究了利血平处理对离体大鼠心脏缺血及再灌注过程中儿茶酚胺和脑啡肽心肌含量以及室性心律失常发生率的影响。2. 利血平处理几乎完全耗尽了心脏中的去甲肾上腺素（NA）。它还显著耗尽了心脏中的肾上腺素和多巴胺。然而，它并未改变脑啡肽的心肌含量。3. 利血平处理显著减轻但并未消除离体心脏制剂中由缺血和再灌注诱导的心律失常。4. 本研究结果表明，心肌儿茶酚胺尤其是NA是缺血和再灌注期间心律失常发生的一个促成因素。