Huilgol Nagraj G
Department of Radiation Oncology, Dr. Balabhai Nanavati Hospital, Mumbai, Maharashtra, India.
J Cancer Res Ther. 2016 Jul-Sep;12(3):1164-1166. doi: 10.4103/0973-1482.194600.
Advanced head and neck cancer continues to have a dismal outcome. Chemoradiation remains the current standard of care. Chemoradiation has not achieved the desired increase in survival in locally advanced head and neck cancer. This is a retrospective analysis of six patients treated with hyperthermia, radiation therapy, and cetuximab. We wished to determine if this combination treatment would further improve the outcome.
Six patients with squamous cell cancer of the head and neck region were treated with hyperthermia, cetuximab, and radiation therapy. The end points assessed were acute toxicity and immediate response.
All the six patients received the planned doses of cetuximab and radiation therapy. Two patients did not complete the planned hyperthermia sessions. All patients developed mucositis and acneiform rashes. None had thermal burns. One hundred percent complete response was observed in all the patients.
Addition of hyperthermia to cetuximab and radiation therapy is feasible and shows impressive response rates with manageable toxicity profile. Further studies evaluating the same are needed to confirm these findings.
晚期头颈癌的治疗效果仍然不佳。放化疗仍是当前的标准治疗方法。在局部晚期头颈癌中，放化疗未能实现预期的生存率提高。这是一项对6例接受热疗、放射治疗和西妥昔单抗治疗患者的回顾性分析。我们希望确定这种联合治疗是否会进一步改善治疗效果。
6例头颈部鳞状细胞癌患者接受了热疗、西妥昔单抗和放射治疗。评估的终点指标为急性毒性和即刻反应。
所有6例患者均接受了计划剂量的西妥昔单抗和放射治疗。2例患者未完成计划的热疗疗程。所有患者均出现了黏膜炎和痤疮样皮疹。无一例发生热烧伤。所有患者均观察到100%的完全缓解。
在西妥昔单抗和放射治疗中加入热疗是可行的，且显示出令人印象深刻的缓解率，毒性反应易于管理。需要进一步开展评估相同治疗方案的研究以证实这些发现。
