Implications of MRGPRX2 in human and experimental cardiometabolic diseases.
作者信息
Azimi Ehsan, Lerner Ethan A
机构信息
Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA.
出版信息
Nat Rev Cardiol. 2017 Feb;14(2):124. doi: 10.1038/nrcardio.2016.212. Epub 2017 Jan 5.
Abstract
摘要
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Dual action of neurokinin-1 antagonists on Mas-related GPCRs.神经激肽-1 拮抗剂对 Mas 相关 GPCR 的双重作用。
JCI Insight. 2016 Oct 6;1(16):e89362. doi: 10.1172/jci.insight.89362.
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Mast cells in human and experimental cardiometabolic diseases.人类和实验性心血管代谢疾病中的肥大细胞。
Nat Rev Cardiol. 2015 Nov;12(11):643-58. doi: 10.1038/nrcardio.2015.117. Epub 2015 Aug 11.
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Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs.重新定义蛋白酶激活受体的概念：组织蛋白酶S通过激活Mrgprs引发瘙痒。
Nat Commun. 2015 Jul 28;6:7864. doi: 10.1038/ncomms8864.
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Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions.鉴定对伪过敏性药物反应至关重要的肥大细胞特异性受体。
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Expression of Mas-related gene X2 on mast cells is upregulated in the skin of patients with severe chronic urticaria.肥大细胞相关基因 X2 在重症慢性荨麻疹患者皮肤中的表达上调。
J Allergy Clin Immunol. 2014 Sep;134(3):622-633.e9. doi: 10.1016/j.jaci.2014.05.004. Epub 2014 Jun 19.
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Tachykinin receptors antagonism for asthma: a systematic review.速激肽受体拮抗剂治疗哮喘：系统评价。
BMC Pulm Med. 2011 Aug 2;11:41. doi: 10.1186/1471-2466-11-41.
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The neuropeptide substance P mediates adventitial mast cell activation and induces intraplaque hemorrhage in advanced atherosclerosis.神经肽 P 介导动脉外膜 mast 细胞激活，并在晚期动脉粥样硬化中诱导斑块内出血。
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Substance P receptor antagonists in the therapy of migraine.
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