Anoh Augustin Etile, Mossoun Arsène, Akoua-Koffi Chantal, Couacy-Hymann Emmanuel, Pauly Maude, Leendertz Siv-Aina, Kouakou N'goran Eliezer, Schubert Grit, Weiss Sabrina, Hofmann Jörg, Leendertz Fabian H, Ehlers Bernhard
1 CHU de Bouaké/Centre de Recherche pour le Développement, Université Alassane Ouattara de Bouake , Bouake, Côte d'Ivoire.
2 UFR Biosciences, Université Félix Houphouët Boigny , Abidjan, Côte d'Ivoire.
Viral Immunol. 2017 Jan/Feb;30(1):54-57. doi: 10.1089/vim.2016.0044.
Human cytomegalovirus (HCMV) is a betaherpesvirus that can be pathogenic to humans. In particular, immunocompromised patients can develop life-threatening symptoms. In the present study, HCMV seroprevalence was investigated in a rural population of Western Côte d'Ivoire. Plasma samples collected from 166 apparently healthy subjects living in 8 villages surrounding the Taï Forest National Park were tested for anti-HCMV immunoglobulin G and M antibody with two commercial enzyme-linked immunosorbent assays. Prevalence of anti-HCMV IgG and IgM antibody was 100% and 5.4%, respectively. Anti-HCMV IgM positive was 10.2% (5/49) of the children and adolescents and 3.4% (4/117) of the adults. This observed decrease of IgM seropositivity and the seroprevalence difference between males and females (3.8% vs. 6.1%) was not statistically significant. In plasma of one IgM-positive participant, a low CMV load was detected indicating low-level replication. A second IgM-positive participant showed signs of local CMV replication. The other seven IgM-positive plasma samples likely reacted nonspecifically or due to polyclonal stimulation. Taken together, the results indicate that HCMV infection is hyperendemic in Côte d'Ivoire.
人类巨细胞病毒（HCMV）是一种可对人类致病的β疱疹病毒。特别是免疫功能低下的患者可能会出现危及生命的症状。在本研究中，对科特迪瓦西部农村人口中的HCMV血清流行率进行了调查。采用两种商用酶联免疫吸附试验，对从塔伊森林国家公园周边8个村庄的166名表面健康的受试者采集的血浆样本进行了抗HCMV免疫球蛋白G和M抗体检测。抗HCMV IgG和IgM抗体的流行率分别为100%和5.4%。抗HCMV IgM阳性在儿童和青少年中占10.2%（5/49），在成年人中占3.4%（4/117）。观察到的IgM血清阳性率下降以及男性和女性之间的血清流行率差异（3.8%对6.1%）无统计学意义。在一名IgM阳性参与者的血浆中检测到低CMV载量，表明病毒复制水平较低。另一名IgM阳性参与者显示出局部CMV复制的迹象。其他七份IgM阳性血浆样本可能是非特异性反应或由于多克隆刺激所致。综上所述，结果表明HCMV感染在科特迪瓦呈高度地方性流行。
