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钒酸盐对糖尿病所致肠道生长及转运影响的逆转作用。

Reversal by vanadate of the effect of diabetes on intestinal growth and transport.

作者信息

Hajjar J J, Dobish M P, Tomicic T K

机构信息

Department of Medicine, Veterans Administration Medical Center, Newington, CT 06111.

出版信息

Diabetes Res. 1989 Mar;10(3):139-41.

PMID:2805588
Abstract

Diabetic changes in small intestinal growth and transport were studied in the rat during the administration of the pentavalent vanadium oxyanion, vanadate. This treatment reversed the effect of diabetes on growth of the intestinal mucosa. It eliminated hyperglycemia and restored the normal rate of absorption of AIB and 3-o-methyl glucose by the intestine. The changes are probably caused by an insulin-like action of vanadate on the intestine.

摘要

在给予大鼠五价钒氧阴离子钒酸盐的过程中,研究了糖尿病对小肠生长和转运的影响。这种治疗逆转了糖尿病对肠黏膜生长的影响。它消除了高血糖症,并恢复了肠道对α-氨基异丁酸(AIB)和3-O-甲基葡萄糖的正常吸收率。这些变化可能是由钒酸盐对肠道的胰岛素样作用引起的。

相似文献

1
Reversal by vanadate of the effect of diabetes on intestinal growth and transport.钒酸盐对糖尿病所致肠道生长及转运影响的逆转作用。
Diabetes Res. 1989 Mar;10(3):139-41.
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Effect of acute and chronic vanadate administration on sugar transport in rat jejunum.急性和慢性给予钒酸盐对大鼠空肠糖转运的影响。
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引用本文的文献

1
Vanadate treatment rapidly improves glucose transport and activates 6-phosphofructo-1-kinase in diabetic rat intestine.钒酸盐处理可迅速改善糖尿病大鼠肠道中的葡萄糖转运并激活6-磷酸果糖-1-激酶。
Diabetologia. 1995 Apr;38(4):403-12. doi: 10.1007/BF00410277.