利用电阻抗肌电图对健康和营养不良动物的肌肉损伤进行无创评估。
Non-invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography.
作者信息
Sanchez Benjamin, Iyer Shama R, Li Jia, Kapur Kush, Xu Su, Rutkove Seward B, Lovering Richard M
机构信息
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Department of Orthopaedics, University of Maryland School of Medicine, AHB, Room 540, 100 Penn Street, Baltimore, Maryland, 21201, USA.
出版信息
Muscle Nerve. 2017 Dec;56(6):E85-E94. doi: 10.1002/mus.25559. Epub 2017 Mar 24.
INTRODUCTION
Dystrophic muscle is particularly susceptible to eccentric contraction-induced injury. We tested the hypothesis that electrical impedance myography (EIM) can detect injury induced by maximal-force lengthening contractions.
METHODS
We induced injury in the quadriceps of wild-type (WT) and dystrophic (mdx) mice with eccentric contractions using an established model.
RESULTS
mdx quadriceps had significantly greater losses in peak twitch and tetany compared with losses in WT quadriceps. Injured muscle showed a significant increase in EIM characteristic frequency in both WT (177 ± 7.7%) and mdx (167 ± 7.8%) quadriceps. EIM also revealed decreased extracellular resistance for both WT and mdx quadriceps after injury.
DISCUSSION
Our results show overall agreement between muscle function and EIM measurements of injured muscle, indicating that EIM is a viable tool to assess injury in dystrophic muscle. Muscle Nerve 56: E85-E94, 2017.
引言
营养不良性肌肉对离心收缩诱导的损伤尤为敏感。我们检验了以下假设：电阻抗肌电图（EIM）能够检测最大力量拉长收缩所诱导的损伤。
方法
我们使用已建立的模型，通过离心收缩在野生型（WT）和营养不良型（mdx）小鼠的股四头肌中诱导损伤。
结果
与WT股四头肌的损失相比，mdx股四头肌在单收缩峰值和强直收缩中的损失显著更大。在WT（177±7.7%）和mdx（167±7.8%）股四头肌中，受损肌肉的EIM特征频率均显著增加。EIM还显示，损伤后WT和mdx股四头肌的细胞外电阻均降低。
讨论
我们的结果表明，肌肉功能与受损肌肉的EIM测量结果总体一致，这表明EIM是评估营养不良性肌肉损伤的一种可行工具。《肌肉与神经》56: E85-E94, 2017年。
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