Boman A, Blute I, Fernström P, Carlfors J, Rydhag L
Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.
Contact Dermatitis. 1989 Aug;21(2):92-104. doi: 10.1111/j.1600-0536.1989.tb04703.x.
Percutaneous absorption of 4 organic solvents (1,1,1-trichloroethane, 1,1,2-trichloroethane, toluene and butanol) from various colloidal preparations in a surfactant-water-organic solvent system was studied in vivo in guinea pigs. The preparations examined were binary solutions of organic solvents and surfactants, o/w emulsions and microemulsions. Phase diagram, birefringence microscopy and droplet size distribution analysis were used for characterization of the preparations. It was found that skin absorption of the solvents depends on the type of surfactant, type of preparation and also on phase equilibria in the systems studied. The presence of nonionic surfactants in the solvents and in a microemulsion with butanol caused skin absorption to decrease. A reduced uptake of solvents from o/w emulsions was observed. The absorption of butanol from a microemulsion with anionic surfactant was greater than from the pure solvent.
在豚鼠体内研究了在表面活性剂 - 水 - 有机溶剂体系中，4种有机溶剂（1,1,1 - 三氯乙烷、1,1,2 - 三氯乙烷、甲苯和丁醇）从各种胶体制剂中的经皮吸收情况。所研究的制剂包括有机溶剂与表面活性剂的二元溶液、油包水乳液和微乳液。利用相图、双折射显微镜和液滴尺寸分布分析对制剂进行表征。结果发现，溶剂的皮肤吸收取决于表面活性剂的类型、制剂的类型以及所研究体系中的相平衡。溶剂中以及与丁醇形成的微乳液中存在非离子表面活性剂会导致皮肤吸收减少。观察到从油包水乳液中溶剂的摄取量减少。含阴离子表面活性剂的微乳液中丁醇的吸收大于纯溶剂中的吸收。
