Szabelska Anna, Tatara Marcin R, Krupski Witold
Department of Prosthetic Dentistry, Medical University in Lublin, ul. Karmelicka 7, 20-081, Lublin, Poland.
Department of Animal Physiology, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, ul. Akademicka 12, 20-950, Lublin, Poland.
BMC Vet Res. 2017 Jan 5;13(1):12. doi: 10.1186/s12917-016-0921-3.
Among bones building the axial and appendicular skeleton, the mandible is characterized by unique morphological and functional traits. The aim of the study was to evaluate morphological, densitometric and mechanical properties of mandible in 5-month-old Polish Merino sheep. Using quantitative computed tomography, volumetric bone mineral density (vBMD) and calcium hydroxyapatite density of the cortical bone (Cb), mean vBMD (MvBMD) and total bone volume were determined. Using computed tomography cross-sectional scans of the mandible, cross-sectional area, second moment of inertia, mean relative wall thickness and cortical index were determined. Three-point bending test was applied to determine mechanical properties. Serum concentration of insulin-like growth factor I (IGF-I) and bone-specific alkaline phosphatase (BAP) was also measured.
All the investigated morphometric, densitometric and mechanical parameters of the right and left mandibular halves were not significantly different (P > 0.05). There was no correlation of final body weight, MvBMD, Cb, BAP and IGF-I with all the analyzed parameters of mandible (P > 0.05). However, positive correlations between the other investigated morphometric, densitometric and mechanical parameter of mandible were found (P < 0.05).
Relationships between morphological, densitometric and mechanical parameters of the mandible indicate that the elaborated experimental model may serve for further studies on metabolic responses of skeletal system to physiological, nutritional, pharmacological, toxicological and environmental factors.
在构成中轴骨骼和附肢骨骼的骨骼中，下颌骨具有独特的形态和功能特征。本研究的目的是评估5月龄波兰美利奴绵羊下颌骨的形态、骨密度和力学性能。使用定量计算机断层扫描，测定皮质骨（Cb）的体积骨矿物质密度（vBMD）和羟基磷灰石钙密度、平均vBMD（MvBMD）和总骨体积。利用下颌骨的计算机断层扫描横断面图像，测定横截面积、惯性矩、平均相对壁厚度和皮质指数。采用三点弯曲试验测定力学性能。还检测了血清胰岛素样生长因子I（IGF-I）和骨特异性碱性磷酸酶（BAP）的浓度。
左右下颌骨各半侧所有研究的形态学、骨密度和力学参数均无显著差异（P>0.05）。最终体重、MvBMD、Cb、BAP和IGF-I与下颌骨所有分析参数均无相关性（P>0.05）。然而，下颌骨其他研究的形态学、骨密度和力学参数之间存在正相关（P<0.05）。
下颌骨形态、骨密度和力学参数之间的关系表明，所建立的实验模型可用于进一步研究骨骼系统对生理、营养、药理、毒理和环境因素的代谢反应。
